Detailed information of TA system TA169954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1112062..1112603
• Replicon: chromosome
• Accession: NZ_CP060092
• Organism: Teredinibacter purpureus strain Bs12

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H5647_RS04845
• Protein ID: WP_045856568.1
• Coordinates: 1112062..1112364 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: H5647_RS04850
• Protein ID: WP_045856744.1
• Coordinates: 1112361..1112603 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5647_RS04825	1107521..1107745	+	225	WP_045856734.1	hypothetical protein	-
H5647_RS04830	1107847..1108230	+	384	WP_045856736.1	hypothetical protein	-
H5647_RS04835	1108362..1108694	+	333	WP_045856738.1	hypothetical protein	-
H5647_RS04840	1111666..1111962	+	297	WP_162926286.1	hypothetical protein	-
H5647_RS04845	1112062..1112364	-	303	WP_045856568.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H5647_RS04850	1112361..1112603	-	243	WP_045856744.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
H5647_RS04855	1112759..1113094	+	336	WP_200911632.1	hypothetical protein	-
H5647_RS04860	1113202..1113618	+	417	WP_045856746.1	hypothetical protein	-
H5647_RS04865	1113750..1114070	+	321	WP_045856748.1	hypothetical protein	-
H5647_RS04870	1114232..1114618	+	387	WP_052691875.1	hypothetical protein	-
H5647_RS04875	1115274..1115627	+	354	WP_045856753.1	DUF4431 domain-containing protein	-
H5647_RS04880	1115727..1116050	+	324	WP_045856755.1	hypothetical protein	-
H5647_RS04885	1116186..1116461	+	276	WP_045856557.1	hypothetical protein	-
H5647_RS04890	1116565..1117002	+	438	WP_045856527.1	DUF3592 domain-containing protein	-
H5647_RS04895	1117119..1117505	+	387	WP_045856759.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1099113..1122856	23743

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11766.49 Da
• Isoelectric Point: 10.5642

>T169954 WP_045856568.1 NZ_CP060092:c1112364-1112062 [Teredinibacter purpureus]
MSAFTLTRRAKTDLKSIAKFTEKRWGREQRYIYIKQFDDTFHVLSNTPEIGNNCNHIKENYQRFPQGSHIIFYRIATQGS
IQIIRILHKNMDVLSKFGGS

Nucleotide

• Length: 303 bp

>T169954 NZ_CP076816:10323-10610 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8895.83 Da
• Isoelectric Point: 4.4651

>AT169954 WP_045856744.1 NZ_CP060092:c1112603-1112361 [Teredinibacter purpureus]
MAKNTSMTLGEHFDGFISHQIQSGRYGSASEVIRAGLRVLEDKESKLDVLRQMLADGEESGTADYSYDSLMRELDAESHI

Nucleotide

• Length: 243 bp

>AT169954 NZ_CP076816:10597-10911 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA