Detailed information of TA system TA169953

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 995025..995554
• Replicon: chromosome
• Accession: NZ_CP060092
• Organism: Teredinibacter purpureus strain Bs12

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H5647_RS04245
• Protein ID: WP_045856568.1
• Coordinates: 995025..995327 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: H5647_RS04250
• Protein ID: WP_045856570.1
• Coordinates: 995324..995554 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5647_RS04205	990914..991411	+	498	WP_045861059.1	GNAT family N-acetyltransferase	-
H5647_RS04210	991513..991872	+	360	WP_045856554.1	hypothetical protein	-
H5647_RS04215	992023..992361	+	339	WP_162926281.1	hypothetical protein	-
H5647_RS04220	992514..992789	+	276	WP_045856557.1	hypothetical protein	-
H5647_RS04225	992893..993672	+	780	WP_045856559.1	hypothetical protein	-
H5647_RS04230	994022..994207	+	186	WP_045856561.1	hypothetical protein	-
H5647_RS04235	994210..994482	+	273	WP_045856563.1	hypothetical protein	-
H5647_RS04240	994647..994922	+	276	WP_045856566.1	hypothetical protein	-
H5647_RS04245	995025..995327	-	303	WP_045856568.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H5647_RS04250	995324..995554	-	231	WP_045856570.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
H5647_RS04255	995560..997065	-	1506	WP_045856572.1	IS66 family transposase	-
H5647_RS04260	997257..998276	+	1020	WP_045856331.1	IS21 family transposase	-
H5647_RS04265	998273..999052	+	780	WP_045855575.1	IS21-like element helper ATPase IstB	-
H5647_RS04270	999104..999409	-	306	WP_045856574.1	IS66 family insertion sequence element accessory protein TnpB	-
H5647_RS04275	999406..999699	-	294	WP_045856576.1	hypothetical protein	-
H5647_RS04280	999985..1000479	+	495	WP_045856578.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	983279..1007603	24324
	-	flank	IS/Tn	-	-	998273..999052	779

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (3-74)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11766.49 Da
• Isoelectric Point: 10.5642

>T169953 WP_045856568.1 NZ_CP060092:c995327-995025 [Teredinibacter purpureus]
MSAFTLTRRAKTDLKSIAKFTEKRWGREQRYIYIKQFDDTFHVLSNTPEIGNNCNHIKENYQRFPQGSHIIFYRIATQGS
IQIIRILHKNMDVLSKFGGS

Nucleotide

• Length: 303 bp

>T169953 NZ_CP076816:4524-4844 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACTAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATTCTACGTCAATTAGTAAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8378.23 Da
• Isoelectric Point: 4.2075

>AT169953 WP_045856570.1 NZ_CP060092:c995554-995324 [Teredinibacter purpureus]
MALTLGEHFDGFISHQIQSGRYGSASEVIRAGLRVLEDKESKLDVLRQMLADGEESGTADYSYDSLMSELDAESHI

Nucleotide

• Length: 231 bp

>AT169953 NZ_CP076816:4837-5109 [Acinetobacter baumannii]
ATGGATAACAACTTATTAGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAGCGTAAGGAGATAAAGGCAAG
TCGAGTCACAGAGCTTGAATTACCGGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCTGAATTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTTTAGATGCTCATCCAACTTTAATTTAA