Detailed information of TA system TA169952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 50262..50778
• Replicon: plasmid p114-1
• Accession: NZ_CP060089
• Organism: Vibrio parahaemolyticus strain TJA114

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H5404_RS24755
• Protein ID: WP_140220082.1
• Coordinates: 50262..50531 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: U2ZH00
• Locus tag: H5404_RS24760
• Protein ID: WP_005526636.1
• Coordinates: 50524..50778 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5404_RS24725	46596..46829	-	234	WP_140220071.1	recombinase family protein	-
H5404_RS24730	46985..47197	+	213	WP_140220072.1	hypothetical protein	-
H5404_RS24735	47277..47711	+	435	WP_140220074.1	hypothetical protein	-
H5404_RS24740	47874..48638	-	765	WP_140220076.1	IS3 family transposase	-
H5404_RS24745	48762..49445	+	684	WP_140220078.1	IS6 family transposase	-
H5404_RS24750	49475..49744	-	270	WP_140220080.1	transposase	-
H5404_RS24755	50262..50531	-	270	WP_140220082.1	Txe/YoeB family addiction module toxin	Toxin
H5404_RS24760	50524..50778	-	255	WP_005526636.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H5404_RS24765	51263..51514	+	252	Protein_59	hypothetical protein	-
H5404_RS24770	51517..51804	+	288	WP_140220084.1	helix-turn-helix domain-containing protein	-
H5404_RS24775	52530..53630	+	1101	WP_140220086.1	OmpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..120965	120965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10618.95 Da
• Isoelectric Point: 7.9816

>T169952 WP_140220082.1 NZ_CP060089:c50531-50262 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDIKRSSFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Nucleotide

• Length: 270 bp

>T169952 NZ_CP076814:1503604-1503786 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9453.60 Da
• Isoelectric Point: 5.0623

>AT169952 WP_005526636.1 NZ_CP060089:c50778-50524 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT169952 NZ_CP076814:1503879-1504283 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Antitoxin

• AlphaFold DB: A0A244CM06