Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 2026795..2027340 | Replicon | chromosome |
| Accession | NZ_CP060088 | ||
| Organism | Vibrio parahaemolyticus strain TJA114 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | H5404_RS17230 | Protein ID | WP_140220228.1 |
| Coordinates | 2027044..2027340 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | H5404_RS17225 | Protein ID | WP_023585842.1 |
| Coordinates | 2026795..2027037 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H5404_RS17170 | 2021951..2022172 | - | 222 | Protein_1770 | transposase | - |
| H5404_RS17175 | 2022378..2023190 | - | 813 | WP_023623438.1 | hypothetical protein | - |
| H5404_RS17180 | 2023700..2023792 | - | 93 | WP_080281584.1 | DUF3265 domain-containing protein | - |
| H5404_RS17185 | 2023807..2024121 | - | 315 | WP_140220237.1 | hypothetical protein | - |
| H5404_RS17190 | 2024438..2024527 | - | 90 | WP_080372495.1 | DUF3265 domain-containing protein | - |
| H5404_RS17195 | 2025154..2025582 | - | 429 | WP_197972206.1 | hypothetical protein | - |
| H5404_RS17200 | 2025611..2025700 | - | 90 | WP_140064799.1 | DUF3265 domain-containing protein | - |
| H5404_RS17205 | 2025731..2026084 | - | 354 | WP_140220232.1 | hypothetical protein | - |
| H5404_RS17210 | 2026124..2026252 | - | 129 | WP_103197551.1 | DUF3265 domain-containing protein | - |
| H5404_RS17215 | 2026243..2026554 | - | 312 | WP_140220230.1 | antibiotic biosynthesis monooxygenase | - |
| H5404_RS17220 | 2026591..2026668 | - | 78 | WP_140220235.1 | DUF3265 domain-containing protein | - |
| H5404_RS17225 | 2026795..2027037 | + | 243 | WP_023585842.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| H5404_RS17230 | 2027044..2027340 | + | 297 | WP_140220228.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H5404_RS17235 | 2027955..2028047 | - | 93 | WP_079880610.1 | DUF3265 domain-containing protein | - |
| H5404_RS17240 | 2028070..2029722 | - | 1653 | WP_185215354.1 | TIGR04141 family sporadically distributed protein | - |
| H5404_RS17245 | 2030014..2030319 | - | 306 | WP_140220241.1 | NIPSNAP family protein | - |
| H5404_RS17250 | 2030373..2030486 | - | 114 | WP_021448828.1 | DUF3265 domain-containing protein | - |
| H5404_RS17255 | 2030492..2031118 | - | 627 | WP_140220239.1 | LysE family translocator | - |
| H5404_RS17260 | 2031267..2031788 | - | 522 | WP_140220257.1 | GNAT family N-acetyltransferase | - |
| H5404_RS17265 | 2031835..2031924 | - | 90 | WP_079866497.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1998174..2054582 | 56408 | |
| - | inside | Integron | - | - | 2004357..2052871 | 48514 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11247.93 Da Isoelectric Point: 9.6946
>T169950 WP_140220228.1 NZ_CP060088:2027044-2027340 [Vibrio parahaemolyticus]
MQKNKYKLSKLAQAHLLKIKNYTVNNFSEMQWRNYKDTLLTGFQMLAGNPEVGRSCDDIYPNGFHFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL
MQKNKYKLSKLAQAHLLKIKNYTVNNFSEMQWRNYKDTLLTGFQMLAGNPEVGRSCDDIYPNGFHFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL
Download Length: 297 bp
>T169950 NZ_CP076813:c5214-4927 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8917.15 Da Isoelectric Point: 5.1006
>AT169950 WP_023585842.1 NZ_CP060088:2026795-2027037 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLKHCFESAKKDLAQGNVVDGEDFLSAL
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLKHCFESAKKDLAQGNVVDGEDFLSAL
Download Length: 243 bp
>AT169950 NZ_CP076813:c4940-4626 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|