Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 2026795..2027340 Replicon chromosome
Accession NZ_CP060088
Organism Vibrio parahaemolyticus strain TJA114

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag H5404_RS17230 Protein ID WP_140220228.1
Coordinates 2027044..2027340 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag H5404_RS17225 Protein ID WP_023585842.1
Coordinates 2026795..2027037 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5404_RS17170 2021951..2022172 - 222 Protein_1770 transposase -
H5404_RS17175 2022378..2023190 - 813 WP_023623438.1 hypothetical protein -
H5404_RS17180 2023700..2023792 - 93 WP_080281584.1 DUF3265 domain-containing protein -
H5404_RS17185 2023807..2024121 - 315 WP_140220237.1 hypothetical protein -
H5404_RS17190 2024438..2024527 - 90 WP_080372495.1 DUF3265 domain-containing protein -
H5404_RS17195 2025154..2025582 - 429 WP_197972206.1 hypothetical protein -
H5404_RS17200 2025611..2025700 - 90 WP_140064799.1 DUF3265 domain-containing protein -
H5404_RS17205 2025731..2026084 - 354 WP_140220232.1 hypothetical protein -
H5404_RS17210 2026124..2026252 - 129 WP_103197551.1 DUF3265 domain-containing protein -
H5404_RS17215 2026243..2026554 - 312 WP_140220230.1 antibiotic biosynthesis monooxygenase -
H5404_RS17220 2026591..2026668 - 78 WP_140220235.1 DUF3265 domain-containing protein -
H5404_RS17225 2026795..2027037 + 243 WP_023585842.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H5404_RS17230 2027044..2027340 + 297 WP_140220228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5404_RS17235 2027955..2028047 - 93 WP_079880610.1 DUF3265 domain-containing protein -
H5404_RS17240 2028070..2029722 - 1653 WP_185215354.1 TIGR04141 family sporadically distributed protein -
H5404_RS17245 2030014..2030319 - 306 WP_140220241.1 NIPSNAP family protein -
H5404_RS17250 2030373..2030486 - 114 WP_021448828.1 DUF3265 domain-containing protein -
H5404_RS17255 2030492..2031118 - 627 WP_140220239.1 LysE family translocator -
H5404_RS17260 2031267..2031788 - 522 WP_140220257.1 GNAT family N-acetyltransferase -
H5404_RS17265 2031835..2031924 - 90 WP_079866497.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1998174..2054582 56408
- inside Integron - - 2004357..2052871 48514


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-54)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11247.93 Da        Isoelectric Point: 9.6946

>T169950 WP_140220228.1 NZ_CP060088:2027044-2027340 [Vibrio parahaemolyticus]
MQKNKYKLSKLAQAHLLKIKNYTVNNFSEMQWRNYKDTLLTGFQMLAGNPEVGRSCDDIYPNGFHFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Download         Length: 297 bp

>T169950 NZ_CP076813:c5214-4927 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8917.15 Da        Isoelectric Point: 5.1006

>AT169950 WP_023585842.1 NZ_CP060088:2026795-2027037 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLKHCFESAKKDLAQGNVVDGEDFLSAL

Download         Length: 243 bp

>AT169950 NZ_CP076813:c4940-4626 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References