Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafN(antitoxin) |
| Location | 2018704..2019269 | Replicon | chromosome |
| Accession | NZ_CP060088 | ||
| Organism | Vibrio parahaemolyticus strain TJA114 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | H5404_RS17135 | Protein ID | WP_039485476.1 |
| Coordinates | 2018704..2018991 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3BLE1 |
| Locus tag | H5404_RS17140 | Protein ID | WP_000086647.1 |
| Coordinates | 2018988..2019269 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H5404_RS17100 | 2014210..2015151 | - | 942 | WP_140220243.1 | DUF1848 domain-containing protein | - |
| H5404_RS17105 | 2015153..2016004 | - | 852 | WP_140220245.1 | hypothetical protein | - |
| H5404_RS17110 | 2016128..2016649 | - | 522 | WP_140220257.1 | GNAT family N-acetyltransferase | - |
| H5404_RS17115 | 2016696..2016848 | - | 153 | WP_079858454.1 | DUF3265 domain-containing protein | - |
| H5404_RS17120 | 2016802..2017293 | - | 492 | WP_080607099.1 | hypothetical protein | - |
| H5404_RS17125 | 2017343..2018194 | - | 852 | WP_153645302.1 | IS3 family transposase | - |
| H5404_RS17130 | 2018278..2018499 | - | 222 | Protein_1762 | transposase | - |
| H5404_RS17135 | 2018704..2018991 | - | 288 | WP_039485476.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H5404_RS17140 | 2018988..2019269 | - | 282 | WP_000086647.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| H5404_RS17145 | 2019459..2019833 | - | 375 | WP_140220247.1 | hypothetical protein | - |
| H5404_RS17150 | 2019876..2019968 | - | 93 | WP_171359308.1 | DUF3265 domain-containing protein | - |
| H5404_RS17155 | 2020423..2020500 | - | 78 | WP_074534512.1 | DUF3265 domain-containing protein | - |
| H5404_RS17160 | 2020534..2020950 | - | 417 | WP_031849395.1 | VOC family protein | - |
| H5404_RS17165 | 2021016..2021867 | - | 852 | WP_153645302.1 | IS3 family transposase | - |
| H5404_RS17170 | 2021951..2022172 | - | 222 | Protein_1770 | transposase | - |
| H5404_RS17175 | 2022378..2023190 | - | 813 | WP_023623438.1 | hypothetical protein | - |
| H5404_RS17180 | 2023700..2023792 | - | 93 | WP_080281584.1 | DUF3265 domain-containing protein | - |
| H5404_RS17185 | 2023807..2024121 | - | 315 | WP_140220237.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1998174..2054582 | 56408 | |
| - | inside | Integron | - | - | 2004357..2052871 | 48514 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11011.68 Da Isoelectric Point: 5.1098
>T169949 WP_039485476.1 NZ_CP060088:c2018991-2018704 [Vibrio parahaemolyticus]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQMLSEDDV
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQMLSEDDV
Download Length: 288 bp
>T169949 NZ_CP076812:c2733257-2732868 [Acinetobacter baumannii]
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCGCAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCGCAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10398.91 Da Isoelectric Point: 5.8650
>AT169949 WP_000086647.1 NZ_CP060088:c2019269-2018988 [Vibrio parahaemolyticus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK
Download Length: 282 bp
>AT169949 NZ_CP076812:c2733521-2733264 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCTTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCTTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|