Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 2007474..2008033 | Replicon | chromosome |
| Accession | NZ_CP060088 | ||
| Organism | Vibrio parahaemolyticus strain TJA114 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | H5404_RS17030 | Protein ID | WP_140220214.1 |
| Coordinates | 2007755..2008033 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | H5404_RS17025 | Protein ID | WP_005398409.1 |
| Coordinates | 2007474..2007758 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H5404_RS16980 | 2002678..2003057 | + | 380 | Protein_1732 | IS30 family transposase | - |
| H5404_RS16985 | 2003435..2003608 | + | 174 | WP_164977343.1 | hypothetical protein | - |
| H5404_RS16990 | 2003811..2004152 | - | 342 | WP_140219843.1 | hypothetical protein | - |
| H5404_RS16995 | 2004370..2004459 | - | 90 | WP_079858491.1 | DUF3265 domain-containing protein | - |
| H5404_RS17000 | 2005451..2005573 | - | 123 | WP_086026910.1 | DUF3265 domain-containing protein | - |
| H5404_RS17005 | 2005570..2006018 | - | 449 | Protein_1737 | GNAT family N-acetyltransferase | - |
| H5404_RS17010 | 2006068..2006919 | - | 852 | WP_153645302.1 | IS3 family transposase | - |
| H5404_RS17015 | 2007003..2007224 | - | 222 | Protein_1739 | transposase | - |
| H5404_RS17020 | 2007272..2007397 | - | 126 | WP_140220212.1 | DUF3265 domain-containing protein | - |
| H5404_RS17025 | 2007474..2007758 | + | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| H5404_RS17030 | 2007755..2008033 | + | 279 | WP_140220214.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H5404_RS17035 | 2008062..2008151 | - | 90 | WP_080259156.1 | DUF3265 domain-containing protein | - |
| H5404_RS17040 | 2008182..2008649 | - | 468 | WP_140220216.1 | hypothetical protein | - |
| H5404_RS17045 | 2008797..2009303 | - | 507 | WP_140202106.1 | hypothetical protein | - |
| H5404_RS17050 | 2009332..2009424 | - | 93 | WP_005526637.1 | DUF3265 domain-containing protein | - |
| H5404_RS17055 | 2009463..2010110 | - | 648 | WP_140220218.1 | PH domain-containing protein | - |
| H5404_RS17060 | 2010760..2011206 | - | 447 | WP_029817141.1 | GNAT family N-acetyltransferase | - |
| H5404_RS25860 | 2011233..2011325 | - | 93 | WP_140203955.1 | DUF3265 domain-containing protein | - |
| H5404_RS17070 | 2011348..2011800 | - | 453 | WP_031780762.1 | hypothetical protein | - |
| H5404_RS17075 | 2011875..2011991 | - | 117 | WP_079379638.1 | DUF3265 domain-containing protein | - |
| H5404_RS17080 | 2012004..2012696 | - | 693 | WP_140220224.1 | hypothetical protein | - |
| H5404_RS17085 | 2012737..2012853 | - | 117 | WP_185215516.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1998174..2054582 | 56408 | |
| - | inside | Integron | - | - | 2004357..2052871 | 48514 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10963.64 Da Isoelectric Point: 4.2698
>T169948 WP_140220214.1 NZ_CP060088:2007755-2008033 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWIEDDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWIEDDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T169948 NZ_CP076809:10323-10610 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT169948 WP_005398409.1 NZ_CP060088:2007474-2007758 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT169948 NZ_CP076809:10597-10911 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|