Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5441547..5442199 Replicon chromosome
Accession NZ_CP060086
Organism Pseudomonas aeruginosa strain JNQH-PA57

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H5409_RS25175 Protein ID WP_003134109.1
Coordinates 5441547..5441957 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H5409_RS25180 Protein ID WP_170869361.1
Coordinates 5441957..5442199 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5409_RS25135 5437829..5438242 - 414 WP_153570846.1 hypothetical protein -
H5409_RS25140 5438253..5438393 + 141 WP_153549538.1 hypothetical protein -
H5409_RS25145 5438550..5439278 + 729 WP_023094843.1 TIGR03761 family integrating conjugative element protein -
H5409_RS25150 5439284..5439817 + 534 WP_003134105.1 DUF3158 family protein -
H5409_RS25155 5439831..5440319 + 489 WP_003134107.1 single-stranded DNA-binding protein -
H5409_RS25160 5440423..5440617 + 195 WP_031632157.1 hypothetical protein -
H5409_RS25165 5440869..5441036 + 168 WP_128729268.1 CrpP family protein -
H5409_RS25170 5441337..5441531 - 195 WP_023094845.1 hypothetical protein -
H5409_RS25175 5441547..5441957 - 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
H5409_RS25180 5441957..5442199 - 243 WP_170869361.1 antitoxin Antitoxin
H5409_RS25185 5442505..5444424 + 1920 WP_003134111.1 type I DNA topoisomerase -
H5409_RS25190 5444432..5445184 + 753 Protein_4982 hypothetical protein -
H5409_RS25195 5445301..5445906 - 606 WP_023094848.1 LysE family translocator -
H5409_RS25200 5446028..5446897 + 870 WP_023094849.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - katA 5424238..5542003 117765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(11-37)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T169945 WP_003134109.1 NZ_CP060086:c5441957-5441547 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

>T169945 NZ_CP076806:c8025-7669 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAGCAACACAAGAGAAAGTCTTAGC
TGCATTGGTTGTTCTACAACAGCAAGGGCCTAGTTTAGGTCGTCCTTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGTGGTAAACCGTTAAGGGCATTTTTTGCATTCGATCCCCTAAGACAAGCGATT
GTGCTGTGTATTGGTGATAAGAGTAATAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATGAGCAATACGCACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8909.94 Da        Isoelectric Point: 4.4230

>AT169945 WP_170869361.1 NZ_CP060086:c5442199-5441957 [Pseudomonas aeruginosa]
MRCVVEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 243 bp

>AT169945 NZ_CP076806:c7676-7374 [Acinetobacter baumannii]
ATGGCTAAGAGCTTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTTTTAGAAAGTCAGCTTCACCTTATCCGAGAAGAGTTAGAAATTTCCCAGAAAGAACTAGCTGCAACCCTTGGAATTA
AACAGCCGTCATTATCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGTGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGGTTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References