Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
Location | 147700..148205 | Replicon | chromosome |
Accession | NZ_CP060086 | ||
Organism | Pseudomonas aeruginosa strain JNQH-PA57 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A3S3VVC5 |
Locus tag | H5409_RS00665 | Protein ID | WP_031640969.1 |
Coordinates | 147700..147981 (-) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A1C7BDS9 |
Locus tag | H5409_RS00670 | Protein ID | WP_003083775.1 |
Coordinates | 147978..148205 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H5409_RS00640 | 142951..144300 | + | 1350 | WP_003137006.1 | C4-dicarboxylate transporter DctA | - |
H5409_RS00645 | 144349..145035 | + | 687 | WP_003083762.1 | FadR family transcriptional regulator | - |
H5409_RS00650 | 145136..145870 | + | 735 | WP_003110658.1 | GntR family transcriptional regulator | - |
H5409_RS00655 | 146074..146460 | + | 387 | WP_003083767.1 | aegerolysin family protein | - |
H5409_RS00660 | 146492..147400 | - | 909 | WP_003083769.1 | LysR family transcriptional regulator | - |
H5409_RS00665 | 147700..147981 | - | 282 | WP_031640969.1 | type II toxin-antitoxin system toxin ParE | Toxin |
H5409_RS00670 | 147978..148205 | - | 228 | WP_003083775.1 | CopG family ribbon-helix-helix protein | Antitoxin |
H5409_RS00675 | 148381..149001 | - | 621 | WP_121382109.1 | hypothetical protein | - |
H5409_RS00680 | 149102..149602 | + | 501 | WP_003101228.1 | LEA type 2 family protein | - |
H5409_RS00685 | 149675..150016 | + | 342 | WP_003101229.1 | alkylphosphonate utilization protein | - |
H5409_RS00690 | 150098..151525 | - | 1428 | WP_003083784.1 | GABA permease | - |
H5409_RS00695 | 151694..153187 | - | 1494 | WP_121381587.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10475.19 Da Isoelectric Point: 10.0435
>T169937 WP_031640969.1 NZ_CP060086:c147981-147700 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T169937 NZ_CP076743:6111-6398 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
Antitoxin
Download Length: 76 a.a. Molecular weight: 8556.58 Da Isoelectric Point: 5.5740
>AT169937 WP_003083775.1 NZ_CP060086:c148205-147978 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ
Download Length: 228 bp
>AT169937 NZ_CP076743:6385-6699 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3S3VVC5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1C7BDS9 |