Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 147700..148205 Replicon chromosome
Accession NZ_CP060086
Organism Pseudomonas aeruginosa strain JNQH-PA57

Toxin (Protein)


Gene name parE Uniprot ID A0A3S3VVC5
Locus tag H5409_RS00665 Protein ID WP_031640969.1
Coordinates 147700..147981 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag H5409_RS00670 Protein ID WP_003083775.1
Coordinates 147978..148205 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5409_RS00640 142951..144300 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
H5409_RS00645 144349..145035 + 687 WP_003083762.1 FadR family transcriptional regulator -
H5409_RS00650 145136..145870 + 735 WP_003110658.1 GntR family transcriptional regulator -
H5409_RS00655 146074..146460 + 387 WP_003083767.1 aegerolysin family protein -
H5409_RS00660 146492..147400 - 909 WP_003083769.1 LysR family transcriptional regulator -
H5409_RS00665 147700..147981 - 282 WP_031640969.1 type II toxin-antitoxin system toxin ParE Toxin
H5409_RS00670 147978..148205 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
H5409_RS00675 148381..149001 - 621 WP_121382109.1 hypothetical protein -
H5409_RS00680 149102..149602 + 501 WP_003101228.1 LEA type 2 family protein -
H5409_RS00685 149675..150016 + 342 WP_003101229.1 alkylphosphonate utilization protein -
H5409_RS00690 150098..151525 - 1428 WP_003083784.1 GABA permease -
H5409_RS00695 151694..153187 - 1494 WP_121381587.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10475.19 Da        Isoelectric Point: 10.0435

>T169937 WP_031640969.1 NZ_CP060086:c147981-147700 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T169937 NZ_CP076743:6111-6398 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT169937 WP_003083775.1 NZ_CP060086:c148205-147978 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT169937 NZ_CP076743:6385-6699 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S3VVC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References