169930

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4481823..4482637 Replicon chromosome
Accession NZ_CP060083
Organism Escherichia coli strain G1/2

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag H4P46_RS22050 Protein ID WP_001054376.1
Coordinates 4481823..4482080 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID B7MMJ3
Locus tag H4P46_RS22055 Protein ID WP_001338189.1
Coordinates 4482092..4482637 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4P46_RS22030 4477111..4478217 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
H4P46_RS22035 4478282..4479262 + 981 WP_000991455.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
H4P46_RS22040 4479845..4480831 - 987 WP_001323209.1 hypothetical protein -
H4P46_RS22045 4481201..4481446 + 246 Protein_4312 GNAT family N-acetyltransferase -
H4P46_RS22050 4481823..4482080 + 258 WP_001054376.1 hypothetical protein Toxin
H4P46_RS22055 4482092..4482637 + 546 WP_001338189.1 N-acetyltransferase Antitoxin
H4P46_RS22060 4482693..4483439 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
H4P46_RS22065 4483608..4483826 + 219 Protein_4316 hypothetical protein -
H4P46_RS22070 4484225..4485346 + 1122 WP_000010829.1 M42 family metallopeptidase -
H4P46_RS22075 4485343..4485621 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
H4P46_RS22080 4485633..4486946 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 4470846..4490854 20008


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T169930 WP_001054376.1 NZ_CP060083:4481823-4482080 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T169930 NZ_CP076736:1910862-1911044 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTTACTATCCCGCATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAAGTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19986.92 Da        Isoelectric Point: 6.3277

>AT169930 WP_001338189.1 NZ_CP060083:4482092-4482637 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT169930 NZ_CP076736:1911109-1911513 [Acinetobacter baumannii]
ATGTTGTATCCAATTGCTATCGAGAGAGGTACAGACACCGAGGCCTTTGGTGTCACCGTTCCAGATATTCCAGGATGTTT
TAGCGCAGGCGATACATTAGAGGAAGCTATCGAGAACGTTAAAGAGGCAATTTCTGGCCACTTAGAAATCCTTGCTGAAG
ATGGAGAAGAAATTCCATTAGCATCTGACTTAGCAAAATTTGTAGATGATCCAGATTATAAAGGCATGATCTGGGCTGTT
ACTGAGGTGGATGTTAGTCGTTATCTTGGTAAGCCTGAAAAAATCAACGTAACTTTACCTAGCCGTTTAATTCGCAAGAT
TGATGATAATGTAGGTAAAGATAAAAGATTTAAAACTCGTTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2KXJ3

References