169923

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2601592..2602118 Replicon chromosome
Accession NZ_CP060083
Organism Escherichia coli strain G1/2

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag H4P46_RS12740 Protein ID WP_000323025.1
Coordinates 2601831..2602118 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag H4P46_RS12735 Protein ID WP_000534858.1
Coordinates 2601592..2601831 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4P46_RS12715 2596954..2597310 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
H4P46_RS12720 2598977..2600290 + 1314 WP_047644851.1 ISNCY family transposase -
H4P46_RS12725 2600727..2601059 - 333 WP_001301033.1 protein FlxA -
H4P46_RS12730 2601262..2601567 - 306 WP_001326990.1 hypothetical protein -
H4P46_RS12735 2601592..2601831 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
H4P46_RS12740 2601831..2602118 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
H4P46_RS12745 2602190..2602345 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
H4P46_RS12750 2602562..2602813 + 252 WP_000980994.1 hypothetical protein -
H4P46_RS12755 2602880..2603158 + 279 WP_012304870.1 hypothetical protein -
H4P46_RS12760 2603160..2604209 + 1050 WP_001265198.1 DUF968 domain-containing protein -
H4P46_RS12765 2604223..2604975 + 753 WP_001047135.1 antitermination protein -
H4P46_RS12770 2605253..2605342 - 90 WP_120795389.1 hypothetical protein -
H4P46_RS12775 2605397..2605609 - 213 WP_000087756.1 cold shock-like protein CspF -
H4P46_RS12780 2605910..2606125 + 216 WP_000066484.1 cold shock-like protein CspB -
H4P46_RS12785 2606879..2607094 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2491600..2655310 163710


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T169923 WP_000323025.1 NZ_CP060083:2601831-2602118 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T169923 NZ_CP076726:3268029-3268163 [Xanthomonas arboricola pv. juglandis]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT169923 WP_000534858.1 NZ_CP060083:2601592-2601831 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT169923 NZ_CP076726:3267794-3267946 [Xanthomonas arboricola pv. juglandis]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References