169913

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1969105..1969936 Replicon chromosome
Accession NZ_CP060083
Organism Escherichia coli strain G1/2

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag H4P46_RS09410 Protein ID WP_000854814.1
Coordinates 1969105..1969479 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag H4P46_RS09415 Protein ID WP_001285585.1
Coordinates 1969568..1969936 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4P46_RS09370 1964501..1965667 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
H4P46_RS09375 1965786..1966259 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
H4P46_RS09380 1966457..1967515 + 1059 WP_001200891.1 FUSC family protein -
H4P46_RS09385 1967687..1968016 + 330 WP_000450409.1 DUF496 family protein -
H4P46_RS09390 1968117..1968299 - 183 WP_001016348.1 hypothetical protein -
H4P46_RS09395 1968326..1968499 + 174 WP_071592185.1 transposase domain-containing protein -
H4P46_RS09400 1968788..1968901 - 114 WP_001161660.1 DUF957 domain-containing protein -
H4P46_RS09405 1968914..1969108 - 195 WP_000988600.1 hypothetical protein -
H4P46_RS09410 1969105..1969479 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
H4P46_RS09415 1969568..1969936 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
H4P46_RS09420 1970010..1970231 - 222 WP_000692323.1 DUF987 domain-containing protein -
H4P46_RS09425 1970294..1970770 - 477 WP_001186773.1 RadC family protein -
H4P46_RS09430 1970786..1971265 - 480 WP_000860076.1 antirestriction protein -
H4P46_RS09435 1971347..1971433 - 87 Protein_1847 DUF945 domain-containing protein -
H4P46_RS09440 1971623..1973164 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
H4P46_RS09445 1973179..1973925 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
H4P46_RS09450 1974011..1974754 - 744 Protein_1850 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T169913 WP_000854814.1 NZ_CP060083:c1969479-1969105 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T169913 NZ_CP076724:c300954-300658 [Geomonas nitrogeniifigens]
CTGTACATCGTCAAGACCCTTCCCGAATTTGACGCTTGGCTAAATGGCATCAAAGACCGCACTACTCGGTTACGGCTGGC
TCGACGCCTTGACAAGGCCCAGCGAGGCAACCTGGGTGATGTGAAACCGGTTGGCCACGGCGTTTTCGAGATGCGTGAGT
TCTTTGGCTCCGGCTGGCGAATGTACTACATAGAACGTGGCAACATCCTTATAGTTATGCTCGGCGGTGGAGACAAGTCC
ACACAAGCAGCCGACATCGCCATTGCCTTCGAGCGGGCAGCCAGATTGGAGGATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT169913 WP_001285585.1 NZ_CP060083:c1969936-1969568 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT169913 NZ_CP076724:c300654-300352 [Geomonas nitrogeniifigens]
ATGCCCAAAAAAGTCGTTGTATCCGACCTGCCAGAATTTGATCTTGCTATGCAGTTAAAAAGCGAAGCCGATATTGCGGC
GTATATCACCATGGTGATTGAAGAAGGTGACGCAGCAGAGTTGGCCCATGCCCTGGGAGTGGCTGCCCGAGCGCGCGGCA
TGGCCGAAATTGCGCATGCTGCCGGTTTGACTCGGGAAGCGCTATATAAAGCCTTACGTCCCGGAGCTCATCCGCGTTTC
GACACGATCAGCAGAGTTTGTTCCGCGCTCGGAGTCCGCTTGGTAGCACAGCCTCGCCATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References