Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4335380..4335975 Replicon chromosome
Accession NZ_CP060075
Organism Escherichia coli strain G3/10

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag H4P47_RS21185 Protein ID WP_000239579.1
Coordinates 4335380..4335730 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag H4P47_RS21190 Protein ID WP_001223208.1
Coordinates 4335724..4335975 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4P47_RS21165 4330829..4331851 - 1023 WP_047401113.1 ABC transporter permease -
H4P47_RS21170 4331865..4333367 - 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
H4P47_RS21175 4333507..4334463 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
H4P47_RS21180 4334773..4335303 + 531 WP_000055072.1 inorganic diphosphatase -
H4P47_RS21185 4335380..4335730 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
H4P47_RS21190 4335724..4335975 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
H4P47_RS21195 4336187..4336528 - 342 WP_047401115.1 gamma-glutamylcyclotransferase -
H4P47_RS21200 4336531..4340310 - 3780 WP_000060891.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T169904 WP_000239579.1 NZ_CP060075:c4335730-4335380 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T169904 NZ_CP076721:244927-245184 [Streptococcus parasuis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGTTCAAAAGCAAATTCGAAAAATGGATAAAACGGCTGCAAGTTTGATTTT
GCGGTATCTTTATAAGCATATCGACGGGTGCGACAACCCTAGACAATACGGAAAAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGTATTGAAGATGACAAAGTGACAGTTACAAGTCTAAAAATG
AGAAATGGAAGCATATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT169904 WP_001223208.1 NZ_CP060075:c4335975-4335724 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT169904 NZ_CP076721:244698-244937 [Streptococcus parasuis]
ATGGCGGCTATTACTTTAAAGGTTTCTGAGCAAGACAAGCTATTTATGCAGGCTATGGCAAAGTTTGAAGGCGTGAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGCAGCTCTCGAAGATGAATACGATGCCCGCGTGGCAGATATTGCTCTGGCAG
AATACCAAGCTGACTTGGCGAATGGAATTGAGCCGATAACACTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References