169858

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4124907..4125721 Replicon chromosome
Accession NZ_CP060065
Organism Escherichia coli strain G5

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag H4P49_RS19875 Protein ID WP_001054376.1
Coordinates 4124907..4125164 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID B7MMJ3
Locus tag H4P49_RS19880 Protein ID WP_001338189.1
Coordinates 4125176..4125721 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4P49_RS19855 4120195..4121301 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
H4P49_RS19860 4121366..4122346 + 981 WP_000991455.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
H4P49_RS19865 4122929..4123915 - 987 WP_001323209.1 hypothetical protein -
H4P49_RS19870 4124285..4124530 + 246 Protein_3886 GNAT family N-acetyltransferase -
H4P49_RS19875 4124907..4125164 + 258 WP_001054376.1 hypothetical protein Toxin
H4P49_RS19880 4125176..4125721 + 546 WP_001338189.1 N-acetyltransferase Antitoxin
H4P49_RS19885 4125777..4126523 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
H4P49_RS19890 4126661..4128274 - 1614 WP_001697975.1 IS66-like element ISEc23 family transposase -
H4P49_RS19895 4128305..4128655 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
H4P49_RS19900 4128652..4129077 - 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
H4P49_RS19905 4129232..4129450 + 219 Protein_3893 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimE / fimB 4116332..4152249 35917


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T169858 WP_001054376.1 NZ_CP060065:4124907-4125164 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T169858 NZ_CP076705:116493-116780 [Escherichia coli O8:H28]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTTAAAGAGTGGCAAAAACTGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGCGAAAGAATGAGATAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19986.92 Da        Isoelectric Point: 6.3277

>AT169858 WP_001338189.1 NZ_CP060065:4125176-4125721 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT169858 NZ_CP076705:116245-116496 [Escherichia coli O8:H28]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAACCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAATCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TTGATGCCCTAGACGATCAGGAGTTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2KXJ3

References