Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 36204..36811 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP060062 | ||
| Organism | Escherichia coli strain G6/7 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | B7LIH8 |
| Locus tag | H4P50_RS26315 | Protein ID | WP_000673985.1 |
| Coordinates | 36204..36590 (-) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | B7LIH9 |
| Locus tag | H4P50_RS26320 | Protein ID | WP_000493532.1 |
| Coordinates | 36587..36811 (-) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H4P50_RS26295 | 32303..33199 | + | 897 | Protein_39 | IS3-like element IS600 family transposase | - |
| H4P50_RS26300 | 33250..34677 | - | 1428 | Protein_40 | DUF4158 domain-containing protein | - |
| H4P50_RS26305 | 34690..35160 | + | 471 | WP_137493084.1 | recombinase family protein | - |
| H4P50_RS26310 | 35329..35607 | + | 279 | WP_032270727.1 | hypothetical protein | - |
| H4P50_RS26315 | 36204..36590 | - | 387 | WP_000673985.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| H4P50_RS26320 | 36587..36811 | - | 225 | WP_000493532.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| H4P50_RS26325 | 37292..37558 | + | 267 | WP_012605122.1 | hypothetical protein | - |
| H4P50_RS26330 | 37652..38647 | - | 996 | WP_052119711.1 | Gfo/Idh/MocA family oxidoreductase | - |
| H4P50_RS26335 | 38658..39545 | - | 888 | WP_016232711.1 | DMT family transporter | - |
| H4P50_RS26340 | 39833..40069 | - | 237 | WP_000887751.1 | hypothetical protein | - |
| H4P50_RS26345 | 40553..40732 | + | 180 | WP_000347021.1 | hypothetical protein | - |
| H4P50_RS26350 | 40848..41186 | - | 339 | WP_016232712.1 | recombinase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..99817 | 99817 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14370.62 Da Isoelectric Point: 7.0732
>T169834 WP_000673985.1 NZ_CP060062:c36590-36204 [Escherichia coli]
MKFVSSQEVIEFHDRLISRDGGVAGMPEPGRADAIIHRVLNMYHYEGVTDIMDLAAVYLVAIARGHIFNDANKRTALFVA
QVFLKRNGVHIISSRISFDEMQIIALNAATGEYNWKMVSDHLKAIILN
MKFVSSQEVIEFHDRLISRDGGVAGMPEPGRADAIIHRVLNMYHYEGVTDIMDLAAVYLVAIARGHIFNDANKRTALFVA
QVFLKRNGVHIISSRISFDEMQIIALNAATGEYNWKMVSDHLKAIILN
Download Length: 387 bp
>T169834 NZ_CP076704:194455-194562 [Escherichia coli O8:H28]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8361.39 Da Isoelectric Point: 5.6713
>AT169834 WP_000493532.1 NZ_CP060062:c36811-36587 [Escherichia coli]
MFTCNYSHARDNLASLLELAVDENQPVEIQRRKGGAAVLVDKDAFERYRKAALDAEFAEIMQSHGTAYTELSKR
MFTCNYSHARDNLASLLELAVDENQPVEIQRRKGGAAVLVDKDAFERYRKAALDAEFAEIMQSHGTAYTELSKR
Download Length: 225 bp
>AT169834 NZ_CP076704:c194398-194341 [Escherichia coli O8:H28]
TCAAGATTAGCCCCCGTTATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
TCAAGATTAGCCCCCGTTATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A086V9Y9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A086V9Y8 |