169831

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4482669..4483483 Replicon chromosome
Accession NZ_CP060061
Organism Escherichia coli strain G6/7

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag H4P50_RS21985 Protein ID WP_001054376.1
Coordinates 4482669..4482926 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID B7MMJ3
Locus tag H4P50_RS21990 Protein ID WP_001338189.1
Coordinates 4482938..4483483 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4P50_RS21965 4477957..4479063 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
H4P50_RS21970 4479128..4480108 + 981 WP_000991455.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
H4P50_RS21975 4480691..4481677 - 987 WP_001323209.1 hypothetical protein -
H4P50_RS21980 4482047..4482292 + 246 Protein_4297 GNAT family N-acetyltransferase -
H4P50_RS21985 4482669..4482926 + 258 WP_001054376.1 hypothetical protein Toxin
H4P50_RS21990 4482938..4483483 + 546 WP_001338189.1 N-acetyltransferase Antitoxin
H4P50_RS21995 4483539..4484285 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
H4P50_RS22000 4484454..4484672 + 219 Protein_4301 hypothetical protein -
H4P50_RS22005 4485071..4486192 + 1122 WP_000010829.1 M42 family metallopeptidase -
H4P50_RS22010 4486189..4486467 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
H4P50_RS22015 4486479..4487792 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 4471692..4491700 20008


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T169831 WP_001054376.1 NZ_CP060061:4482669-4482926 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T169831 NZ_CP076701:2678842-2678976 [Xanthomonas arboricola pv. pruni]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19986.92 Da        Isoelectric Point: 6.3277

>AT169831 WP_001338189.1 NZ_CP060061:4482938-4483483 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT169831 NZ_CP076701:2678607-2678759 [Xanthomonas arboricola pv. pruni]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2KXJ3

References