Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2775507..2776338 Replicon chromosome
Accession NZ_CP060061
Organism Escherichia coli strain G6/7

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag H4P50_RS13585 Protein ID WP_000854814.1
Coordinates 2775964..2776338 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag H4P50_RS13580 Protein ID WP_001285585.1
Coordinates 2775507..2775875 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4P50_RS13545 2770688..2771431 + 744 Protein_2653 DUF945 domain-containing protein -
H4P50_RS13550 2771517..2772264 - 748 Protein_2654 ATP-binding protein -
H4P50_RS13555 2772279..2773820 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
H4P50_RS13560 2774010..2774096 + 87 Protein_2656 DUF945 domain-containing protein -
H4P50_RS13565 2774178..2774657 + 480 WP_000860076.1 antirestriction protein -
H4P50_RS13570 2774673..2775149 + 477 WP_001186773.1 RadC family protein -
H4P50_RS13575 2775212..2775433 + 222 WP_000692323.1 DUF987 domain-containing protein -
H4P50_RS13580 2775507..2775875 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
H4P50_RS13585 2775964..2776338 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
H4P50_RS13590 2776335..2776529 + 195 WP_000988600.1 hypothetical protein -
H4P50_RS13595 2776542..2776655 + 114 WP_001161660.1 DUF957 domain-containing protein -
H4P50_RS13600 2776944..2777117 - 174 WP_071592185.1 transposase domain-containing protein -
H4P50_RS13605 2777144..2777326 + 183 WP_001016348.1 hypothetical protein -
H4P50_RS13610 2777427..2777756 - 330 WP_000450409.1 DUF496 family protein -
H4P50_RS13615 2777928..2778986 - 1059 WP_001200891.1 FUSC family protein -
H4P50_RS13620 2779184..2779657 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
H4P50_RS13625 2779776..2780942 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T169825 WP_000854814.1 NZ_CP060061:2775964-2776338 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T169825 NZ_CP076699:56362-56778 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT169825 WP_001285585.1 NZ_CP060061:2775507-2775875 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT169825 NZ_CP076699:56135-56365 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References