Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 2142628..2143154 | Replicon | chromosome |
Accession | NZ_CP060061 | ||
Organism | Escherichia coli strain G6/7 |
Toxin (Protein)
Gene name | relE | Uniprot ID | S1EXL1 |
Locus tag | H4P50_RS10265 | Protein ID | WP_000323025.1 |
Coordinates | 2142628..2142915 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | S1F6D3 |
Locus tag | H4P50_RS10270 | Protein ID | WP_000534858.1 |
Coordinates | 2142915..2143154 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H4P50_RS10220 | 2137652..2137867 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
H4P50_RS10225 | 2138621..2138836 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
H4P50_RS10230 | 2139137..2139349 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
H4P50_RS10235 | 2139404..2139493 | + | 90 | WP_120795389.1 | hypothetical protein | - |
H4P50_RS10240 | 2139771..2140523 | - | 753 | WP_001047135.1 | antitermination protein | - |
H4P50_RS10245 | 2140537..2141586 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
H4P50_RS10250 | 2141588..2141866 | - | 279 | WP_012304870.1 | hypothetical protein | - |
H4P50_RS10255 | 2141933..2142184 | - | 252 | WP_000980994.1 | hypothetical protein | - |
H4P50_RS10260 | 2142401..2142556 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
H4P50_RS10265 | 2142628..2142915 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
H4P50_RS10270 | 2142915..2143154 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
H4P50_RS10275 | 2143179..2143484 | + | 306 | WP_001326990.1 | hypothetical protein | - |
H4P50_RS10280 | 2143687..2144019 | + | 333 | WP_001301033.1 | protein FlxA | - |
H4P50_RS10285 | 2144456..2145769 | - | 1314 | WP_047644851.1 | ISNCY family transposase | - |
H4P50_RS10290 | 2147436..2147792 | - | 357 | WP_001310834.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 2089302..2253239 | 163937 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T169815 WP_000323025.1 NZ_CP060061:c2142915-2142628 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T169815 NZ_CP076697:c3942076-3941969 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT169815 WP_000534858.1 NZ_CP060061:c2143154-2142915 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT169815 NZ_CP076697:3942133-3942190 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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