169815

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2142628..2143154 Replicon chromosome
Accession NZ_CP060061
Organism Escherichia coli strain G6/7

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag H4P50_RS10265 Protein ID WP_000323025.1
Coordinates 2142628..2142915 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag H4P50_RS10270 Protein ID WP_000534858.1
Coordinates 2142915..2143154 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4P50_RS10220 2137652..2137867 - 216 WP_000839590.1 phage lysis protein EssD -
H4P50_RS10225 2138621..2138836 - 216 WP_000066484.1 cold shock-like protein CspB -
H4P50_RS10230 2139137..2139349 + 213 WP_000087756.1 cold shock-like protein CspF -
H4P50_RS10235 2139404..2139493 + 90 WP_120795389.1 hypothetical protein -
H4P50_RS10240 2139771..2140523 - 753 WP_001047135.1 antitermination protein -
H4P50_RS10245 2140537..2141586 - 1050 WP_001265198.1 DUF968 domain-containing protein -
H4P50_RS10250 2141588..2141866 - 279 WP_012304870.1 hypothetical protein -
H4P50_RS10255 2141933..2142184 - 252 WP_000980994.1 hypothetical protein -
H4P50_RS10260 2142401..2142556 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
H4P50_RS10265 2142628..2142915 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
H4P50_RS10270 2142915..2143154 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
H4P50_RS10275 2143179..2143484 + 306 WP_001326990.1 hypothetical protein -
H4P50_RS10280 2143687..2144019 + 333 WP_001301033.1 protein FlxA -
H4P50_RS10285 2144456..2145769 - 1314 WP_047644851.1 ISNCY family transposase -
H4P50_RS10290 2147436..2147792 - 357 WP_001310834.1 class I SAM-dependent methyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2089302..2253239 163937


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T169815 WP_000323025.1 NZ_CP060061:c2142915-2142628 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T169815 NZ_CP076697:c3942076-3941969 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT169815 WP_000534858.1 NZ_CP060061:c2143154-2142915 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT169815 NZ_CP076697:3942133-3942190 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References