Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 1043660..1044243 | Replicon | chromosome |
Accession | NZ_CP060061 | ||
Organism | Escherichia coli strain G6/7 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | S1EZP4 |
Locus tag | H4P50_RS04940 | Protein ID | WP_000254738.1 |
Coordinates | 1043908..1044243 (+) | Length | 112 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | S1P3W5 |
Locus tag | H4P50_RS04935 | Protein ID | WP_000581937.1 |
Coordinates | 1043660..1043908 (+) | Length | 83 a.a. |
Genomic Context
Location: 1039999..1041300 (1302 bp)
Type: Others
Protein ID: WP_000046812.1
Type: Others
Protein ID: WP_000046812.1
Location: 1041348..1043582 (2235 bp)
Type: Others
Protein ID: WP_000226815.1
Type: Others
Protein ID: WP_000226815.1
Location: 1043660..1043908 (249 bp)
Type: Antitoxin
Protein ID: WP_000581937.1
Type: Antitoxin
Protein ID: WP_000581937.1
Location: 1043908..1044243 (336 bp)
Type: Toxin
Protein ID: WP_000254738.1
Type: Toxin
Protein ID: WP_000254738.1
Location: 1044314..1045105 (792 bp)
Type: Others
Protein ID: WP_001071648.1
Type: Others
Protein ID: WP_001071648.1
Location: 1045333..1046970 (1638 bp)
Type: Others
Protein ID: WP_000210878.1
Type: Others
Protein ID: WP_000210878.1
Location: 1047058..1048356 (1299 bp)
Type: Others
Protein ID: WP_000036723.1
Type: Others
Protein ID: WP_000036723.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H4P50_RS04925 | 1039999..1041300 | + | 1302 | WP_000046812.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
H4P50_RS04930 | 1041348..1043582 | + | 2235 | WP_000226815.1 | GTP pyrophosphokinase | - |
H4P50_RS04935 | 1043660..1043908 | + | 249 | WP_000581937.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
H4P50_RS04940 | 1043908..1044243 | + | 336 | WP_000254738.1 | endoribonuclease MazF | Toxin |
H4P50_RS04945 | 1044314..1045105 | + | 792 | WP_001071648.1 | nucleoside triphosphate pyrophosphohydrolase | - |
H4P50_RS04950 | 1045333..1046970 | + | 1638 | WP_000210878.1 | CTP synthase (glutamine hydrolyzing) | - |
H4P50_RS04955 | 1047058..1048356 | + | 1299 | WP_000036723.1 | phosphopyruvate hydratase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12098.04 Da Isoelectric Point: 8.2618
>T169812 WP_000254738.1 NZ_CP060061:1043908-1044243 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
Download Length: 336 bp
>T169812 NZ_CP076697:c3486816-3486502 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9355.74 Da Isoelectric Point: 4.4665
>AT169812 WP_000581937.1 NZ_CP060061:1043660-1043908 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
Download Length: 249 bp
>AT169812 NZ_CP076697:c3486505-3486089 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA