Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1043660..1044243 Replicon chromosome
Accession NZ_CP060061
Organism Escherichia coli strain G6/7

Toxin (Protein)


Gene name mazF Uniprot ID S1EZP4
Locus tag H4P50_RS04940 Protein ID WP_000254738.1
Coordinates 1043908..1044243 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag H4P50_RS04935 Protein ID WP_000581937.1
Coordinates 1043660..1043908 (+) Length 83 a.a.

Genomic Context


H4P50_RS04925H4P50_RS04930H4P50_RS04935H4P50_RS04940H4P50_RS04945H4P50_RS04950H4P50_RS04955
Location: 1039999..1041300 (1302 bp)
Type: Others
Protein ID: WP_000046812.1
Location: 1041348..1043582 (2235 bp)
Type: Others
Protein ID: WP_000226815.1
Location: 1043660..1043908 (249 bp)
Type: Antitoxin
Protein ID: WP_000581937.1
Location: 1043908..1044243 (336 bp)
Type: Toxin
Protein ID: WP_000254738.1
Location: 1044314..1045105 (792 bp)
Type: Others
Protein ID: WP_001071648.1
Location: 1045333..1046970 (1638 bp)
Type: Others
Protein ID: WP_000210878.1
Location: 1047058..1048356 (1299 bp)
Type: Others
Protein ID: WP_000036723.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H4P50_RS049251039999..1041300+1302WP_000046812.123S rRNA (uracil(1939)-C(5))-methyltransferase RlmD-
H4P50_RS049301041348..1043582+2235WP_000226815.1GTP pyrophosphokinase-
H4P50_RS049351043660..1043908+249WP_000581937.1type II toxin-antitoxin system antitoxin MazEAntitoxin
H4P50_RS049401043908..1044243+336WP_000254738.1endoribonuclease MazFToxin
H4P50_RS049451044314..1045105+792WP_001071648.1nucleoside triphosphate pyrophosphohydrolase-
H4P50_RS049501045333..1046970+1638WP_000210878.1CTP synthase (glutamine hydrolyzing)-
H4P50_RS049551047058..1048356+1299WP_000036723.1phosphopyruvate hydratase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-109)

Antitoxin

(7-51)


Sequences


Toxin        


Download         Length: 112 a.a.        Molecular weight: 12098.04 Da        Isoelectric Point: 8.2618

>T169812 WP_000254738.1 NZ_CP060061:1043908-1044243 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

>T169812 NZ_CP076697:c3486816-3486502 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT169812 WP_000581937.1 NZ_CP060061:1043660-1043908 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp

>AT169812 NZ_CP076697:c3486505-3486089 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
PDB1UB4
PDB5CQX
PDB5CK9
PDB5CKH
PDB5CO7
PDB3NFC
PDB5CR2
PDB5CKB
PDB5CQY
PDB5CKD
PDB5CKE
PDB5CKF


Antitoxin

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Source
ID
Structure
PDB1UB4
PDB5CQX
PDB5CQY
PDB1MVF
PDB2MRN
PDB2MRU
AlphaFold DBA0A7U9LMB4

References