Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 27912..28459 Replicon plasmid unnamed1
Accession NZ_CP060058
Organism Escherichia coli strain G8

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag H4P51_RS26110 Protein ID WP_000969996.1
Coordinates 28178..28459 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID B7LIH2
Locus tag H4P51_RS26105 Protein ID WP_012605119.1
Coordinates 27912..28181 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4P51_RS26070 23179..24368 + 1190 Protein_25 IS4 family transposase -
H4P51_RS26075 24401..24529 - 129 Protein_26 transposase -
H4P51_RS26080 24686..25180 + 495 WP_016232778.1 GNAT family N-acetyltransferase -
H4P51_RS26085 25710..26306 + 597 WP_024192917.1 serine acetyltransferase -
H4P51_RS26090 26406..27023 + 618 WP_016232781.1 hypothetical protein -
H4P51_RS26095 27048..27335 + 288 WP_016232782.1 hypothetical protein -
H4P51_RS26100 27456..27803 + 348 Protein_31 recombinase family protein -
H4P51_RS26105 27912..28181 + 270 WP_012605119.1 hypothetical protein Antitoxin
H4P51_RS26110 28178..28459 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H4P51_RS26115 28494..28652 + 159 Protein_34 3'-5' exonuclease -
H4P51_RS26120 28933..29385 + 453 WP_000670961.1 N-acetyltransferase -
H4P51_RS26125 29440..30756 - 1317 Protein_36 Tn3 family transposase -
H4P51_RS26130 30820..31080 + 261 Protein_37 transposase -
H4P51_RS26135 31145..32296 + 1152 WP_001254932.1 IS30-like element IS30 family transposase -
H4P51_RS26140 32303..33199 + 897 Protein_39 IS3-like element IS600 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..99817 99817
- flank IS/Tn - - 23179..24228 1049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T169805 WP_000969996.1 NZ_CP060058:28178-28459 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T169805 NZ_CP076697:c1923203-1923101 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10200.51 Da        Isoelectric Point: 8.8735

>AT169805 WP_012605119.1 NZ_CP060058:27912-28181 [Escherichia coli]
MTQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLSHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT169805 NZ_CP076697:1923063-1923331 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A0A0GNA3

References