Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4453424..4454238 Replicon chromosome
Accession NZ_CP060057
Organism Escherichia coli strain G8

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag H4P51_RS21835 Protein ID WP_001054376.1
Coordinates 4453424..4453681 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID B7MMJ3
Locus tag H4P51_RS21840 Protein ID WP_001338189.1
Coordinates 4453693..4454238 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4P51_RS21815 4448712..4449818 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
H4P51_RS21820 4449883..4450863 + 981 WP_000991455.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
H4P51_RS21825 4451446..4452432 - 987 WP_001323209.1 hypothetical protein -
H4P51_RS21830 4452802..4453047 + 246 Protein_4267 GNAT family N-acetyltransferase -
H4P51_RS21835 4453424..4453681 + 258 WP_001054376.1 hypothetical protein Toxin
H4P51_RS21840 4453693..4454238 + 546 WP_001338189.1 N-acetyltransferase Antitoxin
H4P51_RS21845 4454294..4455040 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
H4P51_RS21850 4455209..4455427 + 219 Protein_4271 hypothetical protein -
H4P51_RS21855 4455826..4456947 + 1122 WP_000010829.1 M42 family metallopeptidase -
H4P51_RS21860 4456944..4457222 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
H4P51_RS21865 4457234..4458547 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB 4444848..4462455 17607


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T169803 WP_001054376.1 NZ_CP060057:4453424-4453681 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T169803 NZ_CP076697:c1388108-1388001 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19986.92 Da        Isoelectric Point: 6.3277

>AT169803 WP_001338189.1 NZ_CP060057:4453693-4454238 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT169803 NZ_CP076697:1388156-1388222 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2KXJ3

References