Detailed information of TA system TA169798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2777930..2778568
• Replicon: chromosome
• Accession: NZ_CP060057
• Organism: Escherichia coli strain G8

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2X7GI71
• Locus tag: H4P51_RS13590
• Protein ID: WP_032231106.1
• Coordinates: 2778392..2778568 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H4P51_RS13585
• Protein ID: WP_001270286.1
• Coordinates: 2777930..2778346 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4P51_RS13565	2773082..2774023	-	942	WP_001251313.1	ABC transporter permease	-
H4P51_RS13570	2774024..2775037	-	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
H4P51_RS13575	2775055..2776200	-	1146	WP_000047429.1	ABC transporter substrate-binding protein	-
H4P51_RS13580	2776445..2777851	-	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
H4P51_RS13585	2777930..2778346	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
H4P51_RS13590	2778392..2778568	-	177	WP_032231106.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
H4P51_RS13595	2778790..2779020	+	231	WP_000494244.1	YncJ family protein	-
H4P51_RS13600	2779112..2781073	-	1962	WP_001491066.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
H4P51_RS13605	2781146..2781682	-	537	WP_000429151.1	DNA-binding transcriptional regulator SutR	-
H4P51_RS13610	2781735..2782946	+	1212	WP_071528280.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6680.72 Da
• Isoelectric Point: 10.9223

>T169798 WP_032231106.1 NZ_CP060057:c2778568-2778392 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPCHPSDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T169798 NZ_CP076694:c129840-129565 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT169798 WP_001270286.1 NZ_CP060057:c2778346-2777930 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT169798 NZ_CP076694:c130124-129840 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Structures

Toxin

• AlphaFold DB: A0A2X7GI71