Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1980537..1981368 Replicon chromosome
Accession NZ_CP060057
Organism Escherichia coli strain G8

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag H4P51_RS09470 Protein ID WP_000854814.1
Coordinates 1980537..1980911 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag H4P51_RS09475 Protein ID WP_001285585.1
Coordinates 1981000..1981368 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4P51_RS09430 1975933..1977099 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
H4P51_RS09435 1977218..1977691 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
H4P51_RS09440 1977889..1978947 + 1059 WP_001200891.1 FUSC family protein -
H4P51_RS09445 1979119..1979448 + 330 WP_000450409.1 DUF496 family protein -
H4P51_RS09450 1979549..1979731 - 183 WP_001016348.1 hypothetical protein -
H4P51_RS09455 1979758..1979931 + 174 WP_071592185.1 transposase domain-containing protein -
H4P51_RS09460 1980220..1980333 - 114 WP_001161660.1 DUF957 domain-containing protein -
H4P51_RS09465 1980346..1980540 - 195 WP_000988600.1 hypothetical protein -
H4P51_RS09470 1980537..1980911 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
H4P51_RS09475 1981000..1981368 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
H4P51_RS09480 1981442..1981663 - 222 WP_000692323.1 DUF987 domain-containing protein -
H4P51_RS09485 1981726..1982202 - 477 WP_001186773.1 RadC family protein -
H4P51_RS09490 1982218..1982697 - 480 WP_000860076.1 antirestriction protein -
H4P51_RS09495 1982779..1982865 - 87 Protein_1857 DUF945 domain-containing protein -
H4P51_RS09500 1983055..1984594 + 1540 Protein_1858 IS21-like element ISEc12 family transposase -
H4P51_RS09505 1984609..1985355 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
H4P51_RS09510 1985441..1986184 - 744 Protein_1860 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T169786 WP_000854814.1 NZ_CP060057:c1980911-1980537 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T169786 NZ_CP076693:c4012231-4012124 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT169786 WP_001285585.1 NZ_CP060057:c1981368-1981000 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT169786 NZ_CP076693:4012288-4012345 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References