Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 808804..809461 Replicon chromosome
Accession NZ_CP060049
Organism Klebsiella pneumoniae strain NICU_2_P7

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag E4W47_RS04015 Protein ID WP_002916310.1
Coordinates 809051..809461 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag E4W47_RS04010 Protein ID WP_002916312.1
Coordinates 808804..809070 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4W47_RS03985 803960..805393 - 1434 WP_023328360.1 6-phospho-beta-glucosidase BglA -
E4W47_RS03990 805512..806240 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
E4W47_RS03995 806290..806601 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
E4W47_RS04000 806765..807424 + 660 WP_002916317.1 hemolysin III family protein -
E4W47_RS04005 807575..808558 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
E4W47_RS04010 808804..809070 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
E4W47_RS04015 809051..809461 + 411 WP_002916310.1 protein YgfX Toxin
E4W47_RS04020 809468..809989 - 522 WP_004144730.1 flavodoxin FldB -
E4W47_RS04025 810090..810986 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
E4W47_RS04030 811009..811722 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
E4W47_RS04035 811728..813461 + 1734 WP_023328361.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T169758 WP_002916310.1 NZ_CP060049:809051-809461 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T169758 NZ_CP076689:c2336710-2336459 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT169758 WP_002916312.1 NZ_CP060049:808804-809070 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT169758 NZ_CP076689:c2336462-2336208 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References