Detailed information of TA system TA169754

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 788172..788731
• Replicon: chromosome
• Accession: NZ_CP060048
• Organism: Vibrio vulnificus strain 2497-87

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H6S61_RS18930
• Protein ID: WP_045594922.1
• Coordinates: 788172..788450 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2S3SYL7
• Locus tag: H6S61_RS18935
• Protein ID: WP_038963674.1
• Coordinates: 788447..788731 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H6S61_RS18900	783306..784034	+	729	WP_095430004.1	MipA/OmpV family protein	-
H6S61_RS18905	784284..784748	+	465	WP_017420111.1	hypothetical protein	-
H6S61_RS18910	784785..785408	+	624	WP_185893181.1	hypothetical protein	-
H6S61_RS18915	785525..786040	+	516	WP_185893182.1	lipocalin family protein	-
H6S61_RS18920	787610..788035	+	426	Protein_645	hypothetical protein	-
H6S61_RS18925	788032..788154	+	123	WP_072599669.1	DUF3265 domain-containing protein	-
H6S61_RS18930	788172..788450	-	279	WP_045594922.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H6S61_RS18935	788447..788731	-	285	WP_038963674.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H6S61_RS18940	789011..789820	+	810	WP_185893214.1	SUMF1/EgtB/PvdO family nonheme iron enzyme	-
H6S61_RS18945	790052..790315	+	264	WP_017791548.1	hypothetical protein	-
H6S61_RS18950	790393..790893	+	501	WP_185893183.1	hypothetical protein	-
H6S61_RS18955	791174..791704	+	531	WP_043921220.1	hypothetical protein	-
H6S61_RS18960	791799..792227	+	429	WP_185893215.1	hypothetical protein	-
H6S61_RS18965	792298..793323	-	1026	WP_197672410.1	L-threonine 3-dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10919.63 Da
• Isoelectric Point: 4.3430

>T169754 WP_045594922.1 NZ_CP060048:c788450-788172 [Vibrio vulnificus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRCRLLIIPEISMVISYWVEGDIIRVL
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T169754 NZ_CP076689:c1748905-1747583 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCAGCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGATCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11081.45 Da
• Isoelectric Point: 9.2167

>AT169754 WP_038963674.1 NZ_CP060048:c788731-788447 [Vibrio vulnificus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKILSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT169754 NZ_CP076689:c1749171-1748905 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2S3SYL7