Detailed information of TA system TA169753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 337988..338553
• Replicon: chromosome
• Accession: NZ_CP060047
• Organism: Vibrio vulnificus strain 2497-87

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7X8U0A9
• Locus tag: H6S61_RS02205
• Protein ID: WP_029865673.1
• Coordinates: 337988..338275 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: H6S61_RS02210
• Protein ID: WP_000086647.1
• Coordinates: 338272..338553 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H6S61_RS02145	333587..333715	-	129	WP_185892222.1	DUF3265 domain-containing protein	-
H6S61_RS02150	333728..334174	-	447	WP_185891362.1	GNAT family N-acetyltransferase	-
H6S61_RS02155	334323..334673	-	351	WP_185891364.1	hypothetical protein	-
H6S61_RS02160	334707..334796	-	90	WP_185891366.1	DUF3265 domain-containing protein	-
H6S61_RS02165	334825..335256	-	432	WP_185891368.1	hypothetical protein	-
H6S61_RS02170	335274..335396	-	123	WP_185892224.1	DUF3265 domain-containing protein	-
H6S61_RS02175	335405..335740	-	336	WP_038964898.1	hypothetical protein	-
H6S61_RS02180	335767..335859	-	93	WP_072605894.1	DUF3265 domain-containing protein	-
H6S61_RS02185	335889..336257	-	369	WP_029836882.1	hypothetical protein	-
H6S61_RS02190	336513..336881	-	369	WP_185891370.1	hypothetical protein	-
H6S61_RS02195	336850..337020	-	171	WP_185892226.1	DUF3265 domain-containing protein	-
H6S61_RS02200	337362..337490	-	129	WP_185892228.1	DUF3265 domain-containing protein	-
H6S61_RS02205	337988..338275	-	288	WP_029865673.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H6S61_RS02210	338272..338553	-	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H6S61_RS02215	338763..339113	-	351	WP_185891364.1	hypothetical protein	-
H6S61_RS02220	339158..339247	-	90	WP_080607128.1	DUF3265 domain-containing protein	-
H6S61_RS02225	339757..339858	-	102	WP_185892231.1	DUF3265 domain-containing protein	-
H6S61_RS02230	339888..340439	-	552	WP_185891373.1	hypothetical protein	-
H6S61_RS02235	341097..341594	-	498	WP_038964980.1	DUF2867 domain-containing protein	-
H6S61_RS02240	341732..342109	-	378	WP_165386490.1	hypothetical protein	-
H6S61_RS02245	342235..342648	-	414	WP_185891375.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	217740..379394	161654
	-	inside	Integron	-	-	221640..379394	157754

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10993.65 Da
• Isoelectric Point: 5.1098

>T169753 WP_029865673.1 NZ_CP060047:c338275-337988 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Nucleotide

• Length: 288 bp

>T169753 NZ_CP076689:c1479382-1479275 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT169753 WP_000086647.1 NZ_CP060047:c338553-338272 [Vibrio vulnificus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT169753 NZ_CP076689:1479430-1479496 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A7X8U0A9

Antitoxin

• AlphaFold DB: A0A4P8G0X0