Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 298087..298625 | Replicon | chromosome |
| Accession | NZ_CP060047 | ||
| Organism | Vibrio vulnificus strain 2497-87 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | H6S61_RS01790 | Protein ID | WP_017420621.1 |
| Coordinates | 298326..298625 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A0F2HR74 |
| Locus tag | H6S61_RS01785 | Protein ID | WP_011080384.1 |
| Coordinates | 298087..298329 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H6S61_RS01725 | 293492..293620 | - | 129 | WP_130241174.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01730 | 293961..294089 | - | 129 | WP_130199101.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01735 | 294449..294592 | - | 144 | WP_072600879.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01740 | 294555..294968 | - | 414 | WP_038970060.1 | hypothetical protein | - |
| H6S61_RS01745 | 294996..295114 | - | 119 | Protein_349 | DUF3265 domain-containing protein | - |
| H6S61_RS01750 | 295460..295588 | - | 129 | WP_185892183.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01755 | 295946..296038 | - | 93 | WP_079757384.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01760 | 296059..296715 | - | 657 | WP_185891298.1 | hypothetical protein | - |
| H6S61_RS23035 | 296748..296840 | - | 93 | WP_193784990.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01770 | 296855..297262 | - | 408 | WP_103190069.1 | hypothetical protein | - |
| H6S61_RS01775 | 297222..297410 | - | 189 | WP_185892185.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01780 | 297411..297881 | - | 471 | WP_038969900.1 | hypothetical protein | - |
| H6S61_RS01785 | 298087..298329 | + | 243 | WP_011080384.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| H6S61_RS01790 | 298326..298625 | + | 300 | WP_017420621.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H6S61_RS01795 | 298633..298722 | - | 90 | WP_083120101.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01800 | 298758..299327 | - | 570 | WP_185891303.1 | hypothetical protein | - |
| H6S61_RS01805 | 299465..299887 | - | 423 | WP_185891306.1 | GNAT family N-acetyltransferase | - |
| H6S61_RS01810 | 300027..300560 | - | 534 | WP_039842422.1 | cysteine hydrolase | - |
| H6S61_RS01815 | 300579..300701 | - | 123 | WP_080927587.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01820 | 301171..301686 | - | 516 | WP_185891308.1 | GNAT family N-acetyltransferase | - |
| H6S61_RS01825 | 301823..302293 | - | 471 | WP_185891310.1 | GNAT family N-acetyltransferase | - |
| H6S61_RS01830 | 302309..302431 | - | 123 | Protein_366 | DUF3265 domain-containing protein | - |
| H6S61_RS01835 | 302891..303325 | - | 435 | WP_185891312.1 | GNAT family N-acetyltransferase | - |
| H6S61_RS01840 | 303316..303480 | - | 165 | WP_185892188.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 217740..379394 | 161654 | |
| - | inside | Integron | - | - | 221640..379394 | 157754 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11669.37 Da Isoelectric Point: 9.9572
>T169752 WP_017420621.1 NZ_CP060047:298326-298625 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPILGA
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPILGA
Download Length: 300 bp
>T169752 NZ_CP076689:574012-574314 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8953.88 Da Isoelectric Point: 4.2213
>AT169752 WP_011080384.1 NZ_CP060047:298087-298329 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK
Download Length: 243 bp
>AT169752 NZ_CP076689:574350-574691 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|