Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 233769..234314 | Replicon | chromosome |
| Accession | NZ_CP060047 | ||
| Organism | Vibrio vulnificus strain 2497-87 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | H6S61_RS01125 | Protein ID | WP_185891227.1 |
| Coordinates | 234018..234314 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | D0III5 |
| Locus tag | H6S61_RS01120 | Protein ID | WP_000557295.1 |
| Coordinates | 233769..234011 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H6S61_RS01080 | 229678..229980 | - | 303 | WP_185891223.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| H6S61_RS01085 | 229968..230225 | - | 258 | WP_039989820.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| H6S61_RS01090 | 230296..230451 | - | 156 | Protein_217 | DUF3265 domain-containing protein | - |
| H6S61_RS01095 | 230504..231085 | - | 582 | WP_185891225.1 | hypothetical protein | - |
| H6S61_RS01100 | 231967..232311 | - | 345 | WP_010648728.1 | hypothetical protein | - |
| H6S61_RS01105 | 232327..232470 | - | 144 | WP_185892131.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01110 | 232471..232923 | - | 453 | WP_130199172.1 | hypothetical protein | - |
| H6S61_RS01115 | 232951..233040 | - | 90 | WP_080607128.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01120 | 233769..234011 | + | 243 | WP_000557295.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| H6S61_RS01125 | 234018..234314 | + | 297 | WP_185891227.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H6S61_RS01130 | 234487..235083 | - | 597 | WP_185891229.1 | class I SAM-dependent methyltransferase | - |
| H6S61_RS01135 | 235230..235535 | - | 306 | WP_039543047.1 | hypothetical protein | - |
| H6S61_RS01140 | 235564..235656 | - | 93 | WP_017821981.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01145 | 236232..236642 | - | 411 | WP_069507784.1 | hypothetical protein | - |
| H6S61_RS01150 | 236664..236786 | - | 123 | WP_185892134.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01155 | 237271..237633 | - | 363 | WP_180785678.1 | GNAT family N-acetyltransferase | - |
| H6S61_RS01160 | 237660..237752 | - | 93 | WP_202988203.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01165 | 237773..238252 | - | 480 | WP_185891232.1 | lecithin retinol acyltransferase family protein | - |
| H6S61_RS23015 | 238339..238428 | - | 90 | Protein_233 | DUF3265 domain-containing protein | - |
| H6S61_RS01170 | 238518..238916 | + | 399 | WP_185891234.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 217740..379394 | 161654 | |
| - | inside | Integron | - | - | 221640..379394 | 157754 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11292.92 Da Isoelectric Point: 9.6425
>T169748 WP_185891227.1 NZ_CP060047:234018-234314 [Vibrio vulnificus]
MQKNKYKLSKLAQTHLQKIRNYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHSAYFTKEDG
FILVVAVLGQSQLPQNHL
MQKNKYKLSKLAQTHLQKIRNYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHSAYFTKEDG
FILVVAVLGQSQLPQNHL
Download Length: 297 bp
>T169748 NZ_CP076688:49401-49706 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9002.17 Da Isoelectric Point: 4.7914
>AT169748 WP_000557295.1 NZ_CP060047:233769-234011 [Vibrio vulnificus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLAQGNVVDGEDFLNAL
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLAQGNVVDGEDFLNAL
Download Length: 243 bp
>AT169748 NZ_CP076688:49181-49399 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|