Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 229678..230225 | Replicon | chromosome |
| Accession | NZ_CP060047 | ||
| Organism | Vibrio vulnificus strain 2497-87 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | H6S61_RS01080 | Protein ID | WP_185891223.1 |
| Coordinates | 229678..229980 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A240ERD7 |
| Locus tag | H6S61_RS01085 | Protein ID | WP_039989820.1 |
| Coordinates | 229968..230225 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H6S61_RS01025 | 224706..224834 | - | 129 | WP_185892125.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01030 | 225296..225913 | - | 618 | WP_185891212.1 | hypothetical protein | - |
| H6S61_RS01035 | 226118..226420 | - | 303 | WP_038969961.1 | hypothetical protein | - |
| H6S61_RS01040 | 226440..226562 | - | 123 | WP_185892128.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01045 | 226559..227002 | - | 444 | WP_017420781.1 | GNAT family N-acetyltransferase | - |
| H6S61_RS01050 | 227175..227465 | - | 291 | WP_000509889.1 | hypothetical protein | - |
| H6S61_RS01055 | 227485..227607 | - | 123 | WP_185891214.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01060 | 227636..228022 | - | 387 | WP_185891216.1 | tautomerase family protein | - |
| H6S61_RS01065 | 228001..228201 | - | 201 | WP_185891218.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01070 | 228174..228503 | - | 330 | WP_185891220.1 | hypothetical protein | - |
| H6S61_RS01075 | 228663..229190 | - | 528 | WP_202988210.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01080 | 229678..229980 | - | 303 | WP_185891223.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H6S61_RS01085 | 229968..230225 | - | 258 | WP_039989820.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| H6S61_RS01090 | 230296..230451 | - | 156 | Protein_217 | DUF3265 domain-containing protein | - |
| H6S61_RS01095 | 230504..231085 | - | 582 | WP_185891225.1 | hypothetical protein | - |
| H6S61_RS01100 | 231967..232311 | - | 345 | WP_010648728.1 | hypothetical protein | - |
| H6S61_RS01105 | 232327..232470 | - | 144 | WP_185892131.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01110 | 232471..232923 | - | 453 | WP_130199172.1 | hypothetical protein | - |
| H6S61_RS01115 | 232951..233040 | - | 90 | WP_080607128.1 | DUF3265 domain-containing protein | - |
| H6S61_RS01120 | 233769..234011 | + | 243 | WP_000557295.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| H6S61_RS01125 | 234018..234314 | + | 297 | WP_185891227.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| H6S61_RS01130 | 234487..235083 | - | 597 | WP_185891229.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 217740..379394 | 161654 | |
| - | inside | Integron | - | - | 221640..379394 | 157754 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11673.56 Da Isoelectric Point: 5.1765
>T169747 WP_185891223.1 NZ_CP060047:c229980-229678 [Vibrio vulnificus]
MAEVIWTETALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVINPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEVIWTETALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVINPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T169747 NZ_CP076687:4954200-4954535 [Escherichia coli]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACTACGTCATATCTGTCGCCCGTCGTGGTCTGGCAAATATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCGATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTACGGGCGCGGCAGGCTACAGGTCTGCTGCGCCGCCG
CCATAACACGCCATAA
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACTACGTCATATCTGTCGCCCGTCGTGGTCTGGCAAATATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCGATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTACGGGCGCGGCAGGCTACAGGTCTGCTGCGCCGCCG
CCATAACACGCCATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9620.12 Da Isoelectric Point: 6.7269
>AT169747 WP_039989820.1 NZ_CP060047:c230225-229968 [Vibrio vulnificus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT169747 NZ_CP076687:4953834-4954169 [Escherichia coli]
ATGCTGCAAAAGGATAAGGTCATGCAACAAGAATGTGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGCTGATGAAACAACTGGAGCTGAAACTGGCTGACGATGAACTCTCCGCCTGCCAACAACGT
ACCGTCACACTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA
ATGCTGCAAAAGGATAAGGTCATGCAACAAGAATGTGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGCTGATGAAACAACTGGAGCTGAAACTGGCTGACGATGAACTCTCCGCCTGCCAACAACGT
ACCGTCACACTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|