Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 146685..147279 Replicon plasmid pBCPS27
Accession NZ_CP060042
Organism Burkholderia cenocepacia strain PS27

Toxin (Protein)


Gene name PumA Uniprot ID A0A4S3HAC4
Locus tag SY91_RS34795 Protein ID WP_011695197.1
Coordinates 146986..147279 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4S3HA87
Locus tag SY91_RS34790 Protein ID WP_011695198.1
Coordinates 146685..146984 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SY91_RS34775 141944..144052 - 2109 WP_011695201.1 type IV secretion system DNA-binding domain-containing protein -
SY91_RS34780 144045..144446 - 402 WP_011695200.1 hypothetical protein -
SY91_RS34785 146155..146520 + 366 Protein_139 hypothetical protein -
SY91_RS34790 146685..146984 - 300 WP_011695198.1 putative addiction module antidote protein Antitoxin
SY91_RS34795 146986..147279 - 294 WP_011695197.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SY91_RS34800 147383..147526 - 144 WP_154641514.1 hypothetical protein -
SY91_RS34805 147584..147805 - 222 WP_011695196.1 DUF3717 domain-containing protein -
SY91_RS34810 147850..148329 - 480 WP_041489709.1 hypothetical protein -
SY91_RS34815 148376..148642 - 267 WP_011695194.1 hypothetical protein -
SY91_RS34820 149683..151810 - 2128 Protein_146 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..160144 160144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-87)

Antitoxin

Uncharacterized protein HI1420

(4-95)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10826.43 Da        Isoelectric Point: 10.6086

>T169745 WP_011695197.1 NZ_CP060042:c147279-146986 [Burkholderia cenocepacia]
MRIEQTDDFAKWLRGLRDHIARAQIAKRIQRLARGQYGDVKSVGAGVSEMRVHVGPGYRVYFVQRGSTLVILLCGGDKST
QQRDIERAIALSAQLGD

Download         Length: 294 bp

>T169745 NZ_CP076687:4750373-4750546 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10701.99 Da        Isoelectric Point: 4.6364

>AT169745 WP_011695198.1 NZ_CP060042:c146984-146685 [Burkholderia cenocepacia]
MGIKTTPFDAAEYLDTPEAQAEYLRVSFETGDSADIQEAIGTVARARGMTQIARDAGVGRESLYKALDEHGNPEFATILR
VVRALGLTLTVTTPVHEHA

Download         Length: 300 bp

>AT169745 NZ_CP076687:4750049-4750345 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S3HAC4

Antitoxin

Source ID Structure
AlphaFold DB A0A4S3HA87

References