Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 2080451..2080965 Replicon chromosome
Accession NZ_CP060040
Organism Burkholderia cenocepacia strain PS27

Toxin (Protein)


Gene name stbE Uniprot ID A0A7G6V7L5
Locus tag SY91_RS25745 Protein ID WP_006480332.1
Coordinates 2080451..2080669 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7G6V7L6
Locus tag SY91_RS25750 Protein ID WP_034175095.1
Coordinates 2080717..2080965 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SY91_RS25725 2076174..2076872 - 699 WP_006480336.1 MgtC/SapB family protein -
SY91_RS25730 2076988..2078097 + 1110 WP_023477586.1 AGE family epimerase/isomerase -
SY91_RS25735 2078070..2079688 - 1619 Protein_1822 Tar ligand binding domain-containing protein -
SY91_RS25740 2079967..2080410 + 444 WP_006480333.1 PaaI family thioesterase -
SY91_RS25745 2080451..2080669 - 219 WP_006480332.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SY91_RS25750 2080717..2080965 - 249 WP_034175095.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SY91_RS25755 2081093..2082125 - 1033 Protein_1826 CoA transferase -
SY91_RS25760 2082251..2083010 - 760 Protein_1827 helix-turn-helix domain-containing protein -
SY91_RS25765 2083145..2083573 + 429 Protein_1828 enoyl-CoA hydratase/isomerase family protein -
SY91_RS25770 2083947..2084741 - 795 Protein_1829 IclR family transcriptional regulator -
SY91_RS25775 2084709..2085236 + 528 WP_185921222.1 CoA transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-63)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8437.90 Da        Isoelectric Point: 10.6954

>T169742 WP_006480332.1 NZ_CP060040:c2080669-2080451 [Burkholderia cenocepacia]
VRDQFKAKLAERLEHPRIPSAKLHGHPDRYKIKLRGVGYRLVYEVRDAEVIVLVVAVGRRERDAVYLAEMKR

Download         Length: 219 bp

>T169742 NZ_CP076687:c4006628-4006521 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8944.25 Da        Isoelectric Point: 5.0349

>AT169742 WP_034175095.1 NZ_CP060040:c2080965-2080717 [Burkholderia cenocepacia]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNRNEPAFYCIPAKTWEAMVERLEDTDDNAMADSRAREKIVKVNLN
GL

Download         Length: 249 bp

>AT169742 NZ_CP076687:4006685-4006742 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G6V7L5

Antitoxin

Source ID Structure
AlphaFold DB A0A7G6V7L6

References