Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1354726..1355381 Replicon chromosome
Accession NZ_CP060040
Organism Burkholderia cenocepacia strain PS27

Toxin (Protein)


Gene name vapC Uniprot ID A0A7G6V5T4
Locus tag SY91_RS22575 Protein ID WP_006480895.1
Coordinates 1354726..1355145 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7G6V5T5
Locus tag SY91_RS22580 Protein ID WP_034175232.1
Coordinates 1355142..1355381 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SY91_RS22550 1350166..1350960 + 795 WP_006480899.1 AraC family transcriptional regulator -
SY91_RS22555 1351142..1352074 + 933 WP_023477487.1 DMT family transporter -
SY91_RS22560 1352277..1352825 + 549 WP_023477486.1 hypothetical protein -
SY91_RS22565 1352919..1353053 - 135 WP_006485835.1 entericidin A/B family lipoprotein -
SY91_RS22570 1353287..1354582 + 1296 WP_006480896.1 aspartate carbamoyltransferase -
SY91_RS22575 1354726..1355145 - 420 WP_006480895.1 type II toxin-antitoxin system VapC family toxin Toxin
SY91_RS22580 1355142..1355381 - 240 WP_034175232.1 Arc family DNA-binding protein Antitoxin
SY91_RS22585 1355704..1357947 + 2244 WP_023477482.1 TonB-dependent siderophore receptor -
SY91_RS22590 1357951..1358706 + 756 WP_023477481.1 sel1 repeat family protein -
SY91_RS22595 1358703..1359386 + 684 WP_023477480.1 Fe2+-dependent dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-41)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14962.15 Da        Isoelectric Point: 4.9008

>T169738 WP_006480895.1 NZ_CP060040:c1355145-1354726 [Burkholderia cenocepacia]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEQRVVPLFRGRVLPFDD
AASKAYASLRAKARGTGNAMASADGFIAATAAANGLIVATRDVAPFEAAGLRVIDPWAA

Download         Length: 420 bp

>T169738 NZ_CP076687:3372232-3372609 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8747.88 Da        Isoelectric Point: 6.4685

>AT169738 WP_034175232.1 NZ_CP060040:c1355381-1355142 [Burkholderia cenocepacia]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVRPGGRPRLGTLLAEIGREAGGIDFEVRRDASSTDPMSFE

Download         Length: 240 bp

>AT169738 NZ_CP076687:3371775-3372143 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G6V5T4

Antitoxin

Source ID Structure
AlphaFold DB A0A7G6V5T5

References