Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 962177..962816 Replicon chromosome
Accession NZ_CP060040
Organism Burkholderia cenocepacia strain PS27

Toxin (Protein)


Gene name vapC Uniprot ID A0A3N9F707
Locus tag SY91_RS20835 Protein ID WP_011547639.1
Coordinates 962177..962587 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1K469
Locus tag SY91_RS20840 Protein ID WP_011547638.1
Coordinates 962580..962816 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SY91_RS20800 957475..957774 - 300 WP_105797622.1 hypothetical protein -
SY91_RS20805 957986..958234 - 249 WP_006478971.1 hypothetical protein -
SY91_RS20810 958370..958777 + 408 WP_185921423.1 hypothetical protein -
SY91_RS20815 958862..958995 - 134 Protein_844 phenylacetic acid degradation protein PaaY -
SY91_RS20820 959136..960506 + 1371 WP_006478970.1 MFS transporter -
SY91_RS20825 960830..961093 - 264 WP_006483034.1 translation initiation factor IF-1 -
SY91_RS20830 961560..961763 - 204 WP_006483056.1 cold-shock protein -
SY91_RS20835 962177..962587 - 411 WP_011547639.1 type II toxin-antitoxin system VapC family toxin Toxin
SY91_RS20840 962580..962816 - 237 WP_011547638.1 DNA-binding protein Antitoxin
SY91_RS20845 963307..964533 + 1227 WP_185921340.1 acyltransferase -
SY91_RS20850 964553..965230 - 678 WP_175681298.1 hypothetical protein -
SY91_RS20855 965589..965810 + 222 WP_034174773.1 hypothetical protein -
SY91_RS20860 965798..965956 - 159 WP_175806639.1 hypothetical protein -
SY91_RS20865 966064..967452 + 1389 WP_185921341.1 DHA2 family efflux MFS transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 954514..962816 8302


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15202.37 Da        Isoelectric Point: 6.8816

>T169736 WP_011547639.1 NZ_CP060040:c962587-962177 [Burkholderia cenocepacia]
MIDTNVISEIRKGRRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWIAMILSGYAPNILP
VDIETSQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Download         Length: 411 bp

>T169736 NZ_CP076687:c2250100-2249849 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8692.75 Da        Isoelectric Point: 5.0916

>AT169736 WP_011547638.1 NZ_CP060040:c962816-962580 [Burkholderia cenocepacia]
MANLLVRNVDDTIVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLLSMPEVGEDADFQRVQDSGEVRRVFD

Download         Length: 237 bp

>AT169736 NZ_CP076687:c2249852-2249598 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N9F707

Antitoxin

Source ID Structure
AlphaFold DB B1K469

References