Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 859625..861375 | Replicon | chromosome |
| Accession | NZ_CP060040 | ||
| Organism | Burkholderia cenocepacia strain PS27 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A7G6V4I5 |
| Locus tag | SY91_RS20355 | Protein ID | WP_023477873.1 |
| Coordinates | 859625..860965 (-) | Length | 447 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | SY91_RS20360 | Protein ID | WP_023477872.1 |
| Coordinates | 860968..861375 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SY91_RS20335 | 854684..855097 | + | 414 | WP_023477876.1 | PIN domain-containing protein | - |
| SY91_RS20340 | 855170..856471 | - | 1302 | WP_023477875.1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | - |
| SY91_RS20345 | 856676..857983 | - | 1308 | WP_011547704.1 | shikimate transporter | - |
| SY91_RS20350 | 858341..859468 | + | 1128 | WP_023477874.1 | VOC family protein | - |
| SY91_RS20355 | 859625..860965 | - | 1341 | WP_023477873.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| SY91_RS20360 | 860968..861375 | - | 408 | WP_023477872.1 | helix-turn-helix domain-containing protein | Antitoxin |
| SY91_RS20365 | 861828..862493 | - | 666 | WP_023477871.1 | cation diffusion facilitator family transporter | - |
| SY91_RS20370 | 862937..863371 | - | 435 | WP_003131969.1 | mercury resistance transcriptional regulator MerR | - |
| SY91_RS20375 | 863443..863793 | + | 351 | WP_003131974.1 | mercuric ion transporter MerT | - |
| SY91_RS20380 | 863806..864081 | + | 276 | WP_003131987.1 | mercury resistance system periplasmic binding protein MerP | - |
| SY91_RS20385 | 864153..865838 | + | 1686 | WP_003156770.1 | mercury(II) reductase | - |
| SY91_RS20390 | 865856..866221 | + | 366 | WP_000995360.1 | mercury resistance co-regulator MerD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 854684..868131 | 13447 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 447 a.a. Molecular weight: 48982.83 Da Isoelectric Point: 7.7474
>T169734 WP_023477873.1 NZ_CP060040:c860965-859625 [Burkholderia cenocepacia]
MVARARSDRLDLWMNGIPVGYWEIRRGVERLVYLPDWLDDPQGRPLSLSLPFTPGNQPHQGAIVADYFDNLLPDSESIRR
RIAQRYRLRSTAPFELLASIGRDCVGAIQMLPPDETPVDLEAIEGAPLDDAAVANVLRHATATPLPGSGEPDGDLRLSIA
GAQEKTALLRQRNRWLRPSGSTPTTHIFKLPLGRVGNMQADMRTSVENEWLCSKLVAAYGLSVAPCEIGRFDDQKALIVE
RFDRRPSRDGSWILRLPQEDMCQATGTPSGAKYETDGGPGIETIMGILANSADASRDRMNFFVAQLVFWVLAAIDGHAKN
FSIAHLPGNAYRSTPLYDVLSAHPIIGTRRNQIPPRRARLAMAVCGKNRHYVIGEIQPRHWIAQGRRVGLTEDDVRAAMA
AVSARTEPAIAEAAAQIPPDFPADVADAIFAGMRRQSRKLAAADPA
MVARARSDRLDLWMNGIPVGYWEIRRGVERLVYLPDWLDDPQGRPLSLSLPFTPGNQPHQGAIVADYFDNLLPDSESIRR
RIAQRYRLRSTAPFELLASIGRDCVGAIQMLPPDETPVDLEAIEGAPLDDAAVANVLRHATATPLPGSGEPDGDLRLSIA
GAQEKTALLRQRNRWLRPSGSTPTTHIFKLPLGRVGNMQADMRTSVENEWLCSKLVAAYGLSVAPCEIGRFDDQKALIVE
RFDRRPSRDGSWILRLPQEDMCQATGTPSGAKYETDGGPGIETIMGILANSADASRDRMNFFVAQLVFWVLAAIDGHAKN
FSIAHLPGNAYRSTPLYDVLSAHPIIGTRRNQIPPRRARLAMAVCGKNRHYVIGEIQPRHWIAQGRRVGLTEDDVRAAMA
AVSARTEPAIAEAAAQIPPDFPADVADAIFAGMRRQSRKLAAADPA
Download Length: 1341 bp
>T169734 NZ_CP076687:2195931-2196305 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14474.65 Da Isoelectric Point: 11.9664
>AT169734 WP_023477872.1 NZ_CP060040:c861375-860968 [Burkholderia cenocepacia]
MAFPVQTLTQLRPILVGFRKSAGLTQAQLAARLGITQQSYAQLEANPSAVSIERLFKVMNALGVRMTLSLDERDAPAEAA
DSASVAEPVARRKPVASKRGTTAAKTLTGTAVGAARRRPTATTRTTPRVSKREDW
MAFPVQTLTQLRPILVGFRKSAGLTQAQLAARLGITQQSYAQLEANPSAVSIERLFKVMNALGVRMTLSLDERDAPAEAA
DSASVAEPVARRKPVASKRGTTAAKTLTGTAVGAARRRPTATTRTTPRVSKREDW
Download Length: 408 bp
>AT169734 NZ_CP076687:2195474-2195842 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|