Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 266366..266897 Replicon plasmid p1
Accession NZ_CP060037
Organism Sphingobium barthaii strain KK22

Toxin (Protein)


Gene name relE Uniprot ID T0GNF5
Locus tag H5V43_RS22710 Protein ID WP_004212690.1
Coordinates 266616..266897 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID T0G968
Locus tag H5V43_RS22705 Protein ID WP_004212689.1
Coordinates 266366..266629 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5V43_RS22685 261541..263247 + 1707 WP_021238859.1 copper resistance system multicopper oxidase -
H5V43_RS22690 263244..264230 + 987 WP_004212678.1 copper resistance protein B -
H5V43_RS22695 264224..265465 + 1242 WP_007683345.1 MFS transporter -
H5V43_RS22700 265545..265982 + 438 WP_007683347.1 metal-binding protein -
H5V43_RS22705 266366..266629 + 264 WP_004212689.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H5V43_RS22710 266616..266897 + 282 WP_004212690.1 type II toxin-antitoxin system YafQ family toxin Toxin
H5V43_RS22715 267218..267301 + 84 Protein_266 magnesium transporter -
H5V43_RS22720 267299..267993 + 695 Protein_267 IS21 family transposase -
H5V43_RS22725 267980..268708 + 729 WP_025549137.1 IS21-like element helper ATPase IstB -
H5V43_RS22730 268910..269338 + 429 WP_021245211.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..387592 387592
- flank IS/Tn - - 267980..268708 728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-76)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10993.49 Da        Isoelectric Point: 7.4752

>T169731 WP_004212690.1 NZ_CP060037:266616-266897 [Sphingobium barthaii]
MRTIERFGRFKRDYKREKKGQHAKTLDADLIPIIEALASDEPLEPRHRDHALTGDWRDHRDCHIKPDLVLIYRKPDDDTL
QLVRLGSHAELGW

Download         Length: 282 bp

>T169731 NZ_CP076687:c1405639-1405532 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9284.75 Da        Isoelectric Point: 4.5881

>AT169731 WP_004212689.1 NZ_CP060037:266366-266629 [Sphingobium barthaii]
MAANALVQTRIDGAVKEEAATVLAAMGLTVSDAVRLMLTRVARDKALPFEPLVPNAETIEAMKEAREGKGKRFATVVDLM
ADLNADD

Download         Length: 264 bp

>AT169731 NZ_CP076687:1405687-1405753 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T0GNF5

Antitoxin

Source ID Structure
AlphaFold DB T0G968

References