169725

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 15354..16707 Replicon plasmid pBY2
Accession NZ_CP060032
Organism Aeromonas salmonicida subsp. masoucida strain BR19001YR

Toxin (Protein)


Gene name sanaT Uniprot ID A0A807ZF23
Locus tag G7042_RS23195 Protein ID WP_042468256.1
Coordinates 15354..16319 (-) Length 322 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A807ZF76
Locus tag G7042_RS23200 Protein ID WP_042468273.1
Coordinates 16309..16707 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7042_RS23160 11056..11303 + 248 Protein_9 hypothetical protein -
G7042_RS23165 12066..12377 + 312 WP_042468251.1 helix-turn-helix domain-containing protein -
G7042_RS23170 12352..13314 + 963 WP_088814090.1 reverse transcriptase family protein -
G7042_RS23175 13420..13602 - 183 WP_042468252.1 hypothetical protein -
G7042_RS23180 13767..13919 - 153 WP_042468253.1 Hok/Gef family protein -
G7042_RS23185 14427..14924 - 498 WP_042468254.1 hypothetical protein -
G7042_RS23190 14943..15308 - 366 WP_042468255.1 hypothetical protein -
G7042_RS23195 15354..16319 - 966 WP_042468256.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
G7042_RS23200 16309..16707 - 399 WP_042468273.1 S-adenosylhomocysteine hydrolase Antitoxin
G7042_RS23205 17644..18090 + 447 WP_042468257.1 DNA repair protein RadC -
G7042_RS23210 18130..18492 + 363 WP_042468258.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..70953 70953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-302)

Antitoxin

Protein of unknown function DUF6088

(7-128)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 36419.60 Da        Isoelectric Point: 5.4150

>T169725 WP_042468256.1 NZ_CP060032:c16319-15354 [Aeromonas salmonicida subsp. masoucida]
MQPKDSSIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHSCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVEKAEVICRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQEPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHKL
I

Download         Length: 966 bp

>T169725 NZ_CP076683:c1147780-1147130 [[Pseudomonas] zhaodongensis]
ATGGCTAACCACTACCCCAGCCTCAATCCGGAGAAGGCACTGATCTGGCGCATCATCCACCGCGCCAACCTGCCGTGGAT
TCTGGATAGCGGGCTGCATTGCGGCAACAGCGCAGTGAAGGCGCCAGATTGGGTCAATATCGGCAACCCGGAATTGATCG
ATAAGCGTGCCAATCATCCGGTGCCGTTGCCGCCGGGTGGCTGGCTGAACGACTACGTGCCATTCTACTTCACGCCCTTT
TCACCCATGCTGCGCAACATCCACACCGGCTGGGGCGGCATCCAGAAGCGGCCGAATGAAGAGATCGTGATTTTGGTGTC
CAGCCTTCACCACGTTGGCGGGCTGGGTTTGCGGTTCTTGTTCACTGACAGCCATGCCTATTACCAGTGGGCCAATTACT
ACTCGGATCTGGCCGACCTCAACAAGATTGACTGGCCCTTGCTGCAGCGGCGGGACTTCAAGCGCGACCCGGAAGACCCG
GCCAAATTTGAGCGCTACCAGGCCGAGGCACTGATTCACCGGTACTTGCCGGTCGGCGGCCTTCTCGGCATCGTGTGCTA
TACGGAAGCATTAAAACAACGCATTGAGCAGGAGATTCAGGCCCGCAATCTGTACCTGCCGGTTTATGCCCGAACAGGGT
GGTACTTCTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14761.36 Da        Isoelectric Point: 11.0142

>AT169725 WP_042468273.1 NZ_CP060032:c16707-16309 [Aeromonas salmonicida subsp. masoucida]
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQVPAFMEVKPKKRFSRKLKIGSRVFNAA

Download         Length: 399 bp

>AT169725 NZ_CP076683:c1147130-1146054 [[Pseudomonas] zhaodongensis]
ATGATCAGATTCACTCAAGGCAATTTGCTGGAGGCCCGCGCCGAGGCGCTGGTCAACACTGTCAACACCGTCGGTGTGAT
GGGCAAGGGCATCGCGCTGATGTTCAAGGAGCGTTTCGCCGAGAACTTCCGCCGCTACGCTGACGCCTGCAAGGCCAAGG
AAGTGCAAACCGGTAAGATGTTCGTGACCCAGGTACACGAATTGGATGGCCCGCGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGTGCGCGCTCGCGCATGGAGTGGGTGGTGGAAGGCTTACAGGATCTGCGGCGCTTCCTGATCGAGCAACA
GGTTAAGTCCGTCGCCATCCCGCCGCTGGGCGCGGGTAATGGCGGTCTGGAATGGGCGGATGTGCGTGAGCAGATCGAGC
GGGCTTTGGGTGATCTGGACATCGACATTTTGGTGTTCGAGCCCACCAAGCAATACCAGAACGTGGCCAAGCGGGTTGGT
GTAGAAAAGCTCACCCCCGCCCGTGCGCTGATTGCCGAGCTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAGTCT
GCTGGAGATCCAGAAACTGGCGTGGTTTCTGGAGCGTGCCATCGAGCGCTACAACCCGAGCGATAACCCGCTGGACCTGA
AATTCGTGGCGCACAAGTATGGCCCCTACGCGAATCGGCTCGACCATCTTCTAAACAACCTGGATGGCAGCTACCTGCAC
TCCGAAAAGCGTATCAGCGACGCTGATCCACTGGATGTGATCTGGTTTGACGACGAGCGCAGAGCCTTTGTTCAGACCTA
TCTCAAGAGCGAAGCCAAGGCCTACACGCAGGCACTGGAGTCCACGGCGGCACTGATCGATGGCTTTGAGTCGCCTTTCG
GCATGGAGCTGCTGGCCACTGTGGACTGGCTGCTGGCCCGCGAAGGTGTGGCACCCAACGTCCCGGCCTTGCGTGAAGGG
CTGCGCCACTGGCGTGGTGGCCCGGATGCCGCTGCTCGCAAGGATCGCCTCTTTGACGACCGGGCACTAAGCATTGCCCT
GGAGCGCCTGACACAACCTGCTACCGCGCTGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807ZF23

Antitoxin

Source ID Structure
AlphaFold DB A0A807ZF76

References