Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 628768..630394 Replicon chromosome
Accession NZ_CP060029
Organism Acinetobacter baumannii strain AbCTX1

Toxin (Protein)


Gene name hipA Uniprot ID C1IUI3
Locus tag H4B47_RS03065 Protein ID WP_000088044.1
Coordinates 628768..630093 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID C1IUI2
Locus tag H4B47_RS03070 Protein ID WP_000609339.1
Coordinates 630098..630394 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4B47_RS03030 624080..624955 + 876 WP_035895532.1 class A extended-spectrum beta-lactamase CTX-M-115 -
H4B47_RS03035 625126..625611 - 486 WP_200451583.1 hypothetical protein -
H4B47_RS03040 625627..625935 - 309 WP_203469512.1 hypothetical protein -
H4B47_RS03045 626484..626909 - 426 WP_000278471.1 hypothetical protein -
H4B47_RS03050 627162..627977 - 816 WP_001641519.1 HNH endonuclease -
H4B47_RS03055 627990..628400 - 411 WP_000985909.1 hypothetical protein -
H4B47_RS03060 628501..628707 - 207 WP_000134171.1 hypothetical protein -
H4B47_RS03065 628768..630093 - 1326 WP_000088044.1 type II toxin-antitoxin system HipA family toxin Toxin
H4B47_RS03070 630098..630394 - 297 WP_000609339.1 helix-turn-helix transcriptional regulator Antitoxin
H4B47_RS03075 630792..632180 - 1389 WP_000083579.1 hypothetical protein -
H4B47_RS03080 632185..632682 - 498 WP_000340139.1 membrane protein -
H4B47_RS03085 632885..633541 - 657 WP_000462754.1 trypsin-like serine protease -
H4B47_RS03090 634200..634598 - 399 WP_100124976.1 hypothetical protein -
H4B47_RS03095 634619..635074 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catA1 / blaCTX-M-124 / aadA5 / qacE / sul1 / armA / msr(E) / mph(E) / sul2 / ant(2'')-Ia / aph(3')-Ia - 613626..671897 58271


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-71)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50333.32 Da        Isoelectric Point: 6.5044

>T169721 WP_000088044.1 NZ_CP060029:c630093-628768 [Acinetobacter baumannii]
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPDWSADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMRSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGNGQWIIRLPQEDMCQALGISPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIVFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T169721 NZ_CP076679:c4001042-4000638 [Rhodopseudomonas palustris]
GTGACGGCTTTCTTCGATACTGACATTCTAGTCCATGATCAGGAAACCGGCGCGAAAGCGGACCGTGCACGGGCCGTCTT
GGGCGGTGGTGGCAGGCTCAGCGTTCAAGTGTTGAACGAGTTCACCGTCGTGGTGCAGCGCAAGTTCGGCCGGGGGTGGA
GGGAGATCGCCGAGGCTATCGACGACGCTCTGGCTGTGTCCGGGCCGCCACTGCCTCTGACGCAAGATCTGCACGTTGCC
GCTCGCGTGCTCGCTGAGACGTGCAAGCTGTCGTTCTACGACGCGCTGATCGTCGCGGCCGCTCAGGAGGCCGGCTGCGA
GGTGCTGTACAGCGAGGATTTGCAGCACGGCCGCAGCTTCGGCACGTTGCGCGTCGAAAATCCGTTTCTGGAAAATCCGC
GATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10991.49 Da        Isoelectric Point: 10.3134

>AT169721 WP_000609339.1 NZ_CP060029:c630394-630098 [Acinetobacter baumannii]
MINNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSTTASSEG
KQTEEMLKSNSPARQEKW

Download         Length: 297 bp

>AT169721 NZ_CP076679:c4001269-4001039 [Rhodopseudomonas palustris]
ATGAAGGTCTCCAGATGGGGCAATAGCCTTGCCGTCAGGCTGCCGAATGCGCTGGTGGACAAGCTCGATCTGAAAGAGGG
CGACGAGCTCAACGTGGTCGACGTCGCCGAGCGGACGGTGGTGGTCGAGAAGGAGGACAGAAGGAAAGCCGCGCTGGAGC
GCATGGCCGAGCGCAAGTGGAAGTTGCCTGAGGGCTATCGCTTCGATCGTGACGAGGCCAACGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S1XXW1

Antitoxin

Source ID Structure
AlphaFold DB A0A5S9LWW2

References