Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3150788..3151802 Replicon chromosome
Accession NZ_CP060018
Organism Mycolicibacterium holsaticum DSM 44478 = JCM 12374 strain DSM 44478

Toxin (Protein)


Gene name pezT Uniprot ID A0A1E3R3L7
Locus tag H5U41_RS14975 Protein ID WP_069408076.1
Coordinates 3151209..3151802 (+) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A1E3R531
Locus tag H5U41_RS14970 Protein ID WP_069408075.1
Coordinates 3150788..3151177 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5U41_RS14950 (H5U41_14935) 3146028..3147272 + 1245 WP_220693143.1 MBL fold metallo-hydrolase -
H5U41_RS14955 (H5U41_14940) 3147269..3148021 + 753 WP_220693142.1 SDR family oxidoreductase -
H5U41_RS14960 (H5U41_14945) 3148052..3149221 + 1170 WP_220693141.1 cytochrome P450 -
H5U41_RS14965 (H5U41_14950) 3149218..3150228 + 1011 WP_003932518.1 zinc-binding dehydrogenase -
H5U41_RS14970 (H5U41_14955) 3150788..3151177 + 390 WP_069408075.1 hypothetical protein Antitoxin
H5U41_RS14975 (H5U41_14960) 3151209..3151802 + 594 WP_069408076.1 zeta toxin family protein Toxin
H5U41_RS14980 (H5U41_14965) 3152022..3153248 + 1227 WP_220693140.1 prolyl oligopeptidase family serine peptidase -
H5U41_RS14985 (H5U41_14970) 3153269..3153487 + 219 Protein_2974 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-138)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21444.60 Da        Isoelectric Point: 9.7721

>T169718 WP_069408076.1 NZ_CP060018:3151209-3151802 [Mycolicibacterium holsaticum DSM 44478 = JCM 12374]
VKRLDLVVGPNGAGKSTFIELTLAPLLPGSVVVNADEIAKQRWPDDPASHAYEAARIAAATRERLIELGESFIAETVFSH
PSKLELLYSAHLRGYSVVVHAVLIPEQLAVARVQHRVAAGGHSVPEAKIRERYQRLWALVALAAARADSATFYDNSGIRG
PRIVAQMAGGFVVGSLRWPQWTPAALTTCWPNPPDRR

Download         Length: 594 bp

>T169718 NZ_CP076677:4923149-4923343 [Rhodopseudomonas palustris]
ATGAAGGTTCGAGACGTCATTCTGCTGATCGAAGCCGACGGGTGGGTCCACATTGCCACCCGAGGAAGTCACCGGCAGTT
CAAGCATCCCTGGAAGCCTGGCCGGGTCACCATCGCCGGCAAACCGTCCGACGATCTTGCTCCGGGCACGTTTGCCAGTA
TCCTGAAACAGGCTGGTCTGAAGGAGCAGCGCTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13631.90 Da        Isoelectric Point: 4.7352

>AT169718 WP_069408075.1 NZ_CP060018:3150788-3151177 [Mycolicibacterium holsaticum DSM 44478 = JCM 12374]
MTETADRVTRFAADLLDSAAAEGARQSRSAKQQLDHWARVGRAVSGQHSAARRKVEAALSGATPLSELSAEEGVVFNAEI
SAAIQERLADTDYGATLAGRGITTVALNDDGELVQYRPDGTSSTLSDQR

Download         Length: 390 bp

>AT169718 NZ_CP076677:4923343-4923549 [Rhodopseudomonas palustris]
ATGCGCTACGCGGTGGTGATCGAAAAAGCAGAGGGCAACTACTCTGCCTATGTGCCTGATCTGCCCGGCTGCGTGGCAAC
CGGCGACAGCGTCGCTGCCGTCGAGTTTGAGATCCGCGAAGCGATCCGGTTTCACATCGAGGGCCTGAAGGAAGATGGCC
TGCCCGTCCCTGCTCCAACCAGTCTGGCGGAGTACGTCGAGACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3R3L7

Antitoxin

Source ID Structure
AlphaFold DB A0A1E3R531

References