Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4389860..4390500 Replicon chromosome
Accession NZ_CP060015
Organism Mycobacterium malmoense strain DSM 44163

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H5T25_RS20240 Protein ID WP_083011411.1
Coordinates 4390102..4390500 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H5T25_RS20235 Protein ID WP_071510511.1
Coordinates 4389860..4390105 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5T25_RS20220 (H5T25_20075) 4386274..4387866 - 1593 WP_083011413.1 serine hydrolase -
H5T25_RS20225 (H5T25_20080) 4387886..4389001 - 1116 WP_083011412.1 MBL fold metallo-hydrolase -
H5T25_RS20230 (H5T25_20085) 4389007..4389735 - 729 WP_071510510.1 enoyl-CoA hydratase -
H5T25_RS20235 (H5T25_20090) 4389860..4390105 + 246 WP_071510511.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H5T25_RS20240 (H5T25_20095) 4390102..4390500 + 399 WP_083011411.1 type II toxin-antitoxin system VapC family toxin Toxin
H5T25_RS20245 (H5T25_20100) 4390587..4392059 + 1473 WP_083011410.1 carboxyl transferase domain-containing protein -
H5T25_RS20250 (H5T25_20105) 4392365..4393528 - 1164 WP_139797096.1 hypothetical protein -
H5T25_RS20255 (H5T25_20110) 4394101..4394616 - 516 WP_071510515.1 GNAT family N-acetyltransferase -
H5T25_RS20260 (H5T25_20115) 4394617..4394895 - 279 WP_230981487.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14140.83 Da        Isoelectric Point: 4.0492

>T169710 WP_083011411.1 NZ_CP060015:4390102-4390500 [Mycobacterium malmoense]
VIVDTSAVIAILTEEDDAAVYAEALAGADTCRLSAASYLECGIVLDSQRDPIISRALDELMQEAQCVVEPVTERQARLAR
QAYADFGKGSGHPAGLNFGDCLSYALASDLREPLLWKGNDFGYTGIRSALDQ

Download         Length: 399 bp

>T169710 NZ_CP076676:c4165826-4165425 [Rhodopseudomonas palustris]
GTGACGCGCTATATGCTCGATACCAGCATTCTCTCCGATCTGATCCGCAATCCGCACGGCGCGGCTGTTCGCCGCATCGC
CGAGGTCGGGGAGGGCAACGTCTGCACGAGTATCATCGTCGCCGCCGAACTCCGCTACGGCTGTGCCAAGAGCGGGTCGG
TCAAATTGACCAAGGCCGTGGCCGATCTGCTCGAAGAAATCGACGTGCTGCCGTTCGAGCCGCCCGCCGACGAAGTCTAT
GGGGCGATCCGCTCATCGCTTGAAGCAGCAGGCACGCCGATCGGCAGCAACGACCTCCTGATCGCAGCTCATGCCAAGTC
GCTCGGTGCGACCATCGTCACCGCGAACACGCAGAAGTTTGGTCGCGTGCAGGGTTTGGCAGTCGAGAACTGGCTGGCGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8836.10 Da        Isoelectric Point: 9.9250

>AT169710 WP_071510511.1 NZ_CP060015:4389860-4390105 [Mycobacterium malmoense]
MALNIKDASIHEAVKQIAKITGESQTQAVATAVQERLARLQRDDLTARILAIGHKTAGRMSSETKQLDHATLLYDQRGLP
A

Download         Length: 246 bp

>AT169710 NZ_CP076676:c4166059-4165823 [Rhodopseudomonas palustris]
ATGACCGATCGGCGCCATGTCCGTCTGTTCCGTAACGGCCGCAATCAGGCCGTTCGCATTCCGGTGGAATTCGAGATGCC
CGGCAACGAGGCGATCATGCACCGCGAGGGGGATCGGTTGGTGATCGAGCCGGTCCGCAAACGCGGACTGATCGCTTTGT
TGAAATCGATGACGCCGGTCGACGAGCCATTCCCCGTCATCGACGATCCCGCGCCGGCCCCGGAGAAGGTGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References