Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 4383171..4383834 Replicon chromosome
Accession NZ_CP060015
Organism Mycobacterium malmoense strain DSM 44163

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag H5T25_RS20205 Protein ID WP_083011414.1
Coordinates 4383171..4383641 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag H5T25_RS20210 Protein ID WP_071510531.1
Coordinates 4383646..4383834 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5T25_RS20180 (H5T25_20035) 4378589..4379827 + 1239 WP_254893618.1 MFS transporter -
H5T25_RS20185 (H5T25_20040) 4379855..4381336 - 1482 WP_083011415.1 DUF4185 domain-containing protein -
H5T25_RS20190 (H5T25_20045) 4381839..4382021 + 183 Protein_4007 carotenoid oxygenase family protein -
H5T25_RS20195 (H5T25_20050) 4382202..4382678 + 477 WP_139797102.1 VOC family protein -
H5T25_RS20200 (H5T25_20055) 4382683..4383108 - 426 WP_071510505.1 hypothetical protein -
H5T25_RS20205 (H5T25_20060) 4383171..4383641 - 471 WP_083011414.1 SRPBCC family protein Toxin
H5T25_RS20210 (H5T25_20065) 4383646..4383834 - 189 WP_071510531.1 antitoxin Antitoxin
H5T25_RS20215 (H5T25_20070) 4383878..4386277 - 2400 WP_071510507.1 cation-translocating P-type ATPase -
H5T25_RS20220 (H5T25_20075) 4386274..4387866 - 1593 WP_083011413.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17132.83 Da        Isoelectric Point: 9.5924

>T169709 WP_083011414.1 NZ_CP060015:c4383641-4383171 [Mycobacterium malmoense]
MAKLSGSIDVPLPPEVAWKHASDLSRYREWLTIHRVWRSTLPDEIEKGTVIESIVEVKGMLNRIRWTVVHYKPPQGMTLN
GDGVGGVKVKLMAKIQPKDEGSVVGFDVHLGGPALFGPIGMIVAAALRSDINESLHNFVRVFTAPDPQMNGDGGRR

Download         Length: 471 bp

>T169709 NZ_CP076676:c3889356-3888823 [Rhodopseudomonas palustris]
ATGGCGGACATAGACGACGCGCCAAACCAGCCACGCTCCCGTCTGTCGGCTCCTGTTCCCCTGACGATGCAACATGATTT
GTCGGCGTTCGATTGCGGTGAGCCGGTGTTGAACGACTGGCTGCGCCAACGGGCACTCAAGAACGAAAGCCGATTCTCGC
GCACCTACGTGGTGTGCGAAGGCAACAAGGTCGTCGGCTATTTCTGCGTTTCAGCGGGCGCGGTCGAGCGCGCCGCAGCG
CCCGGCAAGGTCCGCCGCAACGCGCCCGACACGATCCCGGTGTCGGTCATCGGACGACTGGCCGTCAGCCGCTCCCATGC
CGGAAGCGGGCTCGGCGCCGACCTGCTTTCGGACGCGCTGCGCCGGATCGCGCTGGCATCGCAGAGCATCGGCATCGGCG
CGGTTCTGGTTCACGCCAAGGACGATGCGGCCAAACGCTTCTATCTGCGCTGCGCCGAATTCATCGAATATCCCGAAGAC
AGCTGGACGTTGTTCCTGCCGATCGAAGCGGTGGTCGCGGCTTTGAGTGAGTAG

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6605.29 Da        Isoelectric Point: 5.0336

>AT169709 WP_071510531.1 NZ_CP060015:c4383834-4383646 [Mycobacterium malmoense]
VGFLDKAKDLLAQNADKVETAIDKAGEFVDGKTKGKYSDTIHKVQEEAKKAAESAGPGDQQN

Download         Length: 189 bp

>AT169709 NZ_CP076676:c3889682-3889344 [Rhodopseudomonas palustris]
ATGGCAAAGACGCGTGTCGCACCTGCAAAATCTGCTCGTCGTTCCGCTGCGGCCGCAGCGCGCGGCGCGACGTCCGACGC
CAAGGGCAGCATCAATCTGCGGATCGAGACCGGCACCCGCCAACTGATCGACGATGCGGCGGCGGTGCTGGGGAAGACGC
GTACCGAGTTCATGGTGGAAAGCGCCCGTCGGCAGGCGGTCGATGTGTTGCTCGATCAGCGCTTATTCACGCTCGATCCC
GAACGCTATGACGCCTTCATGCAGGCGCTCGACAATCCGCCCGCGCCGGGGCCGAAGCTCAAGGCGTTGCTGCGTCGGGT
CCCGGCATGGCGGACATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References