Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 4147082..4147755 Replicon chromosome
Accession NZ_CP060015
Organism Mycobacterium malmoense strain DSM 44163

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H5T25_RS19095 Protein ID WP_083012383.1
Coordinates 4147082..4147519 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H5T25_RS19100 Protein ID WP_071509811.1
Coordinates 4147516..4147755 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5T25_RS19060 (H5T25_18920) 4142879..4143223 - 345 Protein_3785 hypothetical protein -
H5T25_RS19065 (H5T25_18925) 4143316..4143663 + 348 WP_139797194.1 hypothetical protein -
H5T25_RS19070 (H5T25_18930) 4143638..4144816 - 1179 WP_139797193.1 hypothetical protein -
H5T25_RS19075 4145327..4145716 - 390 WP_230981427.1 hypothetical protein -
H5T25_RS19080 (H5T25_18935) 4145904..4146302 - 399 WP_071509808.1 VOC family protein -
H5T25_RS19085 (H5T25_18940) 4146441..4146704 - 264 WP_083012388.1 type II toxin-antitoxin system RelE/ParE family toxin -
H5T25_RS19090 (H5T25_18945) 4146701..4146979 - 279 WP_083012385.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
H5T25_RS19095 (H5T25_18950) 4147082..4147519 - 438 WP_083012383.1 type II toxin-antitoxin system VapC family toxin Toxin
H5T25_RS19100 (H5T25_18955) 4147516..4147755 - 240 WP_071509811.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H5T25_RS19105 (H5T25_18960) 4147829..4148926 - 1098 WP_083012380.1 redox-regulated ATPase YchF -
H5T25_RS19110 (H5T25_18965) 4149040..4150161 + 1122 WP_176220073.1 hypothetical protein -
H5T25_RS19115 (H5T25_18970) 4150169..4151179 - 1011 WP_083012435.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
H5T25_RS19120 (H5T25_18975) 4151265..4151849 + 585 WP_083012378.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4143316..4153388 10072


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-125)

Antitoxin

SpoVT-AbrB domain

(4-33)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 14926.76 Da        Isoelectric Point: 6.4901

>T169708 WP_083012383.1 NZ_CP060015:c4147519-4147082 [Mycobacterium malmoense]
VTGRRLSVDTSVAVPLLVASHERHHAVAEWARGRSLSLSSHALAETYSVLTRLPGDARVAPADAVTLIDENFDEVLVLSA
TAARGAHRELAANGVAGGATYDGLVALAGREHGAVLVSRDARARSTYETLGVAVEVLVGAAGPAQ

Download         Length: 438 bp

>T169708 NZ_CP076676:2426018-2426896 [Rhodopseudomonas palustris]
ATGGCTAAAGCACCAACCAATGTAGCGAAATCGGTCAAGGACCGGCTACTCAATATCGCCCGCAAAGAAGGTCGCGCATT
CGACGTCCTGCTGGTGCGGTTCGCGCTCGAACGGCTACTTTATCGCCTCTCGATCTCAGCGCATAGCGACCGCTTCGTCC
TGAAAGGTGGCATGCTGGTCACGGTCTGGGTGGCCGACGACAATCGGGTGACGCGGGATGCGGACTTTCTCGGACATGGG
GACGCCGATCCTGACCGTCTGATCGCCGACTTCGGGGAGATCATGGCAATCGAGAGCGACGATGGCCTTGCCTTCGATAT
CGACGCGCTCGCTGCGATGGTTATTCGAGAGGAGATGGAATACGGGGGCGTTCGCCTCAAAACCGCGGCCTATCTCGAAA
GGACGCGCATTCCCGTTACTATCGACATCGGTTTCGGAGACGCTATGGCCGATGCGACGCAGCGGCTCGACTATCCGACA
TTGCTGGATCTTCCCGCCCCACAGGTTCGTTGCTATCCGCCCGCCACGGTGATCGCCAAGAAATTCCAGGCAATGGTGGA
GCTCGGCGTCCTCAACGGACGCATGAAGGACTATTACGACCTGTGGGCGATCCCACGCGCGATCGACATTTCCGCGGACG
ATCTGGATGCGGCCATCATCGCGACGTTCGAGCGCCGGCGGACGCCGATCCCGAAGGAACGTCCACCAGGTCTCTCGGCC
GAAATGTTCGGCGACGAAGGGAAACAGCGGCAATGGCGTGCTTACGCCGCATCGCTTGAACTCGATGCTATTTCGCTGGA
ATCGATCATCGAAGCGGTTTGGGAGTTGGTCGGTCCGTCATGCGCGCGGATCGTAGCAAGAAGCGACAGTGAGGCATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8395.53 Da        Isoelectric Point: 5.7808

>AT169708 WP_071509811.1 NZ_CP060015:c4147755-4147516 [Mycobacterium malmoense]
MEAVIDSGGRVVLPKHLRDALGLTPGTTVDISPYGTGVQVTPGGRTARLEREADGRLVSRGDAAVTDEMMYALIDSVRR

Download         Length: 240 bp

>AT169708 NZ_CP076676:2425405-2426025 [Rhodopseudomonas palustris]
ATGCGCGCGAGGCACGATTCGCAAAAGGCCCAGCTCATCAGCCTGCTCGAGACGCGCAGCATGATGCGCGCGCAGGACCT
GCGGGAGGCTGGCATCAGTGCGCAAACGATCGCACGGGCCGTCGAGGCGGGGGAAATCGACCGTATCTCGCGCGGAGTTT
ATCAGAAGCGTGGCGTGGAGGTCGAAGAGAACCAGATCCTAGCTGAAGCCCTCATGCGTGCCTCCAAAGGCGTCATCGCT
ATGGTGTCGGCGCTCGCCTTCCATGGACTGACCGACCAAATGCCACGGCGCGTTTGGATGGCGATCGGGACGAGCGATTG
GGCGCCCGTGCAGTCCTATCCCCCTCTGCGCATAGTCCGTTTCACGCAGCCTTACCTGCGACAAGGCATCGAGCATCATG
TCATCTCTGGACTCGACGTCCCGATCTATTCGATCCCGAAGACGCTTGCCGACCTCTTCCGAAACCCCAAACTCGTCGAC
CGGTCAGTCGCTGTAGAAGGCCTGCGAGCTGCTCTTCAGCAACGCAAGGCCACTCCGAGCGCAATCGCCCACGCCGCGAA
GGCCGGCGGTGCTTGGAAGGTAATGCAACCCTATCTGGAGGCGCTTACCTCCAATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References