Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/AbrB(antitoxin) |
Location | 4147082..4147755 | Replicon | chromosome |
Accession | NZ_CP060015 | ||
Organism | Mycobacterium malmoense strain DSM 44163 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | H5T25_RS19095 | Protein ID | WP_083012383.1 |
Coordinates | 4147082..4147519 (-) | Length | 146 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | H5T25_RS19100 | Protein ID | WP_071509811.1 |
Coordinates | 4147516..4147755 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H5T25_RS19060 (H5T25_18920) | 4142879..4143223 | - | 345 | Protein_3785 | hypothetical protein | - |
H5T25_RS19065 (H5T25_18925) | 4143316..4143663 | + | 348 | WP_139797194.1 | hypothetical protein | - |
H5T25_RS19070 (H5T25_18930) | 4143638..4144816 | - | 1179 | WP_139797193.1 | hypothetical protein | - |
H5T25_RS19075 | 4145327..4145716 | - | 390 | WP_230981427.1 | hypothetical protein | - |
H5T25_RS19080 (H5T25_18935) | 4145904..4146302 | - | 399 | WP_071509808.1 | VOC family protein | - |
H5T25_RS19085 (H5T25_18940) | 4146441..4146704 | - | 264 | WP_083012388.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
H5T25_RS19090 (H5T25_18945) | 4146701..4146979 | - | 279 | WP_083012385.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
H5T25_RS19095 (H5T25_18950) | 4147082..4147519 | - | 438 | WP_083012383.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
H5T25_RS19100 (H5T25_18955) | 4147516..4147755 | - | 240 | WP_071509811.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
H5T25_RS19105 (H5T25_18960) | 4147829..4148926 | - | 1098 | WP_083012380.1 | redox-regulated ATPase YchF | - |
H5T25_RS19110 (H5T25_18965) | 4149040..4150161 | + | 1122 | WP_176220073.1 | hypothetical protein | - |
H5T25_RS19115 (H5T25_18970) | 4150169..4151179 | - | 1011 | WP_083012435.1 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | - |
H5T25_RS19120 (H5T25_18975) | 4151265..4151849 | + | 585 | WP_083012378.1 | lipid droplet-associated protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 4143316..4153388 | 10072 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 146 a.a. Molecular weight: 14926.76 Da Isoelectric Point: 6.4901
>T169708 WP_083012383.1 NZ_CP060015:c4147519-4147082 [Mycobacterium malmoense]
VTGRRLSVDTSVAVPLLVASHERHHAVAEWARGRSLSLSSHALAETYSVLTRLPGDARVAPADAVTLIDENFDEVLVLSA
TAARGAHRELAANGVAGGATYDGLVALAGREHGAVLVSRDARARSTYETLGVAVEVLVGAAGPAQ
VTGRRLSVDTSVAVPLLVASHERHHAVAEWARGRSLSLSSHALAETYSVLTRLPGDARVAPADAVTLIDENFDEVLVLSA
TAARGAHRELAANGVAGGATYDGLVALAGREHGAVLVSRDARARSTYETLGVAVEVLVGAAGPAQ
Download Length: 438 bp
>T169708 NZ_CP076676:2426018-2426896 [Rhodopseudomonas palustris]
ATGGCTAAAGCACCAACCAATGTAGCGAAATCGGTCAAGGACCGGCTACTCAATATCGCCCGCAAAGAAGGTCGCGCATT
CGACGTCCTGCTGGTGCGGTTCGCGCTCGAACGGCTACTTTATCGCCTCTCGATCTCAGCGCATAGCGACCGCTTCGTCC
TGAAAGGTGGCATGCTGGTCACGGTCTGGGTGGCCGACGACAATCGGGTGACGCGGGATGCGGACTTTCTCGGACATGGG
GACGCCGATCCTGACCGTCTGATCGCCGACTTCGGGGAGATCATGGCAATCGAGAGCGACGATGGCCTTGCCTTCGATAT
CGACGCGCTCGCTGCGATGGTTATTCGAGAGGAGATGGAATACGGGGGCGTTCGCCTCAAAACCGCGGCCTATCTCGAAA
GGACGCGCATTCCCGTTACTATCGACATCGGTTTCGGAGACGCTATGGCCGATGCGACGCAGCGGCTCGACTATCCGACA
TTGCTGGATCTTCCCGCCCCACAGGTTCGTTGCTATCCGCCCGCCACGGTGATCGCCAAGAAATTCCAGGCAATGGTGGA
GCTCGGCGTCCTCAACGGACGCATGAAGGACTATTACGACCTGTGGGCGATCCCACGCGCGATCGACATTTCCGCGGACG
ATCTGGATGCGGCCATCATCGCGACGTTCGAGCGCCGGCGGACGCCGATCCCGAAGGAACGTCCACCAGGTCTCTCGGCC
GAAATGTTCGGCGACGAAGGGAAACAGCGGCAATGGCGTGCTTACGCCGCATCGCTTGAACTCGATGCTATTTCGCTGGA
ATCGATCATCGAAGCGGTTTGGGAGTTGGTCGGTCCGTCATGCGCGCGGATCGTAGCAAGAAGCGACAGTGAGGCATAA
ATGGCTAAAGCACCAACCAATGTAGCGAAATCGGTCAAGGACCGGCTACTCAATATCGCCCGCAAAGAAGGTCGCGCATT
CGACGTCCTGCTGGTGCGGTTCGCGCTCGAACGGCTACTTTATCGCCTCTCGATCTCAGCGCATAGCGACCGCTTCGTCC
TGAAAGGTGGCATGCTGGTCACGGTCTGGGTGGCCGACGACAATCGGGTGACGCGGGATGCGGACTTTCTCGGACATGGG
GACGCCGATCCTGACCGTCTGATCGCCGACTTCGGGGAGATCATGGCAATCGAGAGCGACGATGGCCTTGCCTTCGATAT
CGACGCGCTCGCTGCGATGGTTATTCGAGAGGAGATGGAATACGGGGGCGTTCGCCTCAAAACCGCGGCCTATCTCGAAA
GGACGCGCATTCCCGTTACTATCGACATCGGTTTCGGAGACGCTATGGCCGATGCGACGCAGCGGCTCGACTATCCGACA
TTGCTGGATCTTCCCGCCCCACAGGTTCGTTGCTATCCGCCCGCCACGGTGATCGCCAAGAAATTCCAGGCAATGGTGGA
GCTCGGCGTCCTCAACGGACGCATGAAGGACTATTACGACCTGTGGGCGATCCCACGCGCGATCGACATTTCCGCGGACG
ATCTGGATGCGGCCATCATCGCGACGTTCGAGCGCCGGCGGACGCCGATCCCGAAGGAACGTCCACCAGGTCTCTCGGCC
GAAATGTTCGGCGACGAAGGGAAACAGCGGCAATGGCGTGCTTACGCCGCATCGCTTGAACTCGATGCTATTTCGCTGGA
ATCGATCATCGAAGCGGTTTGGGAGTTGGTCGGTCCGTCATGCGCGCGGATCGTAGCAAGAAGCGACAGTGAGGCATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8395.53 Da Isoelectric Point: 5.7808
>AT169708 WP_071509811.1 NZ_CP060015:c4147755-4147516 [Mycobacterium malmoense]
MEAVIDSGGRVVLPKHLRDALGLTPGTTVDISPYGTGVQVTPGGRTARLEREADGRLVSRGDAAVTDEMMYALIDSVRR
MEAVIDSGGRVVLPKHLRDALGLTPGTTVDISPYGTGVQVTPGGRTARLEREADGRLVSRGDAAVTDEMMYALIDSVRR
Download Length: 240 bp
>AT169708 NZ_CP076676:2425405-2426025 [Rhodopseudomonas palustris]
ATGCGCGCGAGGCACGATTCGCAAAAGGCCCAGCTCATCAGCCTGCTCGAGACGCGCAGCATGATGCGCGCGCAGGACCT
GCGGGAGGCTGGCATCAGTGCGCAAACGATCGCACGGGCCGTCGAGGCGGGGGAAATCGACCGTATCTCGCGCGGAGTTT
ATCAGAAGCGTGGCGTGGAGGTCGAAGAGAACCAGATCCTAGCTGAAGCCCTCATGCGTGCCTCCAAAGGCGTCATCGCT
ATGGTGTCGGCGCTCGCCTTCCATGGACTGACCGACCAAATGCCACGGCGCGTTTGGATGGCGATCGGGACGAGCGATTG
GGCGCCCGTGCAGTCCTATCCCCCTCTGCGCATAGTCCGTTTCACGCAGCCTTACCTGCGACAAGGCATCGAGCATCATG
TCATCTCTGGACTCGACGTCCCGATCTATTCGATCCCGAAGACGCTTGCCGACCTCTTCCGAAACCCCAAACTCGTCGAC
CGGTCAGTCGCTGTAGAAGGCCTGCGAGCTGCTCTTCAGCAACGCAAGGCCACTCCGAGCGCAATCGCCCACGCCGCGAA
GGCCGGCGGTGCTTGGAAGGTAATGCAACCCTATCTGGAGGCGCTTACCTCCAATGGCTAA
ATGCGCGCGAGGCACGATTCGCAAAAGGCCCAGCTCATCAGCCTGCTCGAGACGCGCAGCATGATGCGCGCGCAGGACCT
GCGGGAGGCTGGCATCAGTGCGCAAACGATCGCACGGGCCGTCGAGGCGGGGGAAATCGACCGTATCTCGCGCGGAGTTT
ATCAGAAGCGTGGCGTGGAGGTCGAAGAGAACCAGATCCTAGCTGAAGCCCTCATGCGTGCCTCCAAAGGCGTCATCGCT
ATGGTGTCGGCGCTCGCCTTCCATGGACTGACCGACCAAATGCCACGGCGCGTTTGGATGGCGATCGGGACGAGCGATTG
GGCGCCCGTGCAGTCCTATCCCCCTCTGCGCATAGTCCGTTTCACGCAGCCTTACCTGCGACAAGGCATCGAGCATCATG
TCATCTCTGGACTCGACGTCCCGATCTATTCGATCCCGAAGACGCTTGCCGACCTCTTCCGAAACCCCAAACTCGTCGAC
CGGTCAGTCGCTGTAGAAGGCCTGCGAGCTGCTCTTCAGCAACGCAAGGCCACTCCGAGCGCAATCGCCCACGCCGCGAA
GGCCGGCGGTGCTTGGAAGGTAATGCAACCCTATCTGGAGGCGCTTACCTCCAATGGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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