Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 4146441..4146979 | Replicon | chromosome |
| Accession | NZ_CP060015 | ||
| Organism | Mycobacterium malmoense strain DSM 44163 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | H5T25_RS19085 | Protein ID | WP_083012388.1 |
| Coordinates | 4146441..4146704 (-) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | H5T25_RS19090 | Protein ID | WP_083012385.1 |
| Coordinates | 4146701..4146979 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H5T25_RS19050 (H5T25_18910) | 4141643..4141966 | - | 324 | WP_083012398.1 | putative quinol monooxygenase | - |
| H5T25_RS19055 (H5T25_18915) | 4141986..4142498 | - | 513 | WP_083012395.1 | OsmC family protein | - |
| H5T25_RS19060 (H5T25_18920) | 4142879..4143223 | - | 345 | Protein_3785 | hypothetical protein | - |
| H5T25_RS19065 (H5T25_18925) | 4143316..4143663 | + | 348 | WP_139797194.1 | hypothetical protein | - |
| H5T25_RS19070 (H5T25_18930) | 4143638..4144816 | - | 1179 | WP_139797193.1 | hypothetical protein | - |
| H5T25_RS19075 | 4145327..4145716 | - | 390 | WP_230981427.1 | hypothetical protein | - |
| H5T25_RS19080 (H5T25_18935) | 4145904..4146302 | - | 399 | WP_071509808.1 | VOC family protein | - |
| H5T25_RS19085 (H5T25_18940) | 4146441..4146704 | - | 264 | WP_083012388.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H5T25_RS19090 (H5T25_18945) | 4146701..4146979 | - | 279 | WP_083012385.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| H5T25_RS19095 (H5T25_18950) | 4147082..4147519 | - | 438 | WP_083012383.1 | type II toxin-antitoxin system VapC family toxin | - |
| H5T25_RS19100 (H5T25_18955) | 4147516..4147755 | - | 240 | WP_071509811.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| H5T25_RS19105 (H5T25_18960) | 4147829..4148926 | - | 1098 | WP_083012380.1 | redox-regulated ATPase YchF | - |
| H5T25_RS19110 (H5T25_18965) | 4149040..4150161 | + | 1122 | WP_176220073.1 | hypothetical protein | - |
| H5T25_RS19115 (H5T25_18970) | 4150169..4151179 | - | 1011 | WP_083012435.1 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | - |
| H5T25_RS19120 (H5T25_18975) | 4151265..4151849 | + | 585 | WP_083012378.1 | lipid droplet-associated protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4143316..4153388 | 10072 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10117.71 Da Isoelectric Point: 10.4008
>T169706 WP_083012388.1 NZ_CP060015:c4146704-4146441 [Mycobacterium malmoense]
VTYRIELTGAARKALTESLPEAVAVACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYQIFDERVVVRIIYIA
HRRDVYR
VTYRIELTGAARKALTESLPEAVAVACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYQIFDERVVVRIIYIA
HRRDVYR
Download Length: 264 bp
>T169706 NZ_CP076676:c1701692-1701375 [Rhodopseudomonas palustris]
ATGAAGGTCAGCAAACTGAAGAAGTTCAACGCGGCCGAACACCTTCGTACACCGGAAGCACGCGCGGAGTATCTGAACAT
CGTTCTCGCCGACGGCGACCCCAACGAAGTGCGTGACGCACTCAATCTCGTCGCTCGCGCGCAGGGCATGAGCGCGATCG
CCAAGGCCGCTGGCGTCACCAGAGAGGGACTCTACAAGACGCTCGGTGAGAATGGTAACCCCGAGTTCGCAACCATCCTC
CGGGTGTTCGGCGCCATGGGATTCCGGTTGACGGCAGAACTGGCCGAAAATAAGCCGAGAAGGAAAGCAGTGGCCTGA
ATGAAGGTCAGCAAACTGAAGAAGTTCAACGCGGCCGAACACCTTCGTACACCGGAAGCACGCGCGGAGTATCTGAACAT
CGTTCTCGCCGACGGCGACCCCAACGAAGTGCGTGACGCACTCAATCTCGTCGCTCGCGCGCAGGGCATGAGCGCGATCG
CCAAGGCCGCTGGCGTCACCAGAGAGGGACTCTACAAGACGCTCGGTGAGAATGGTAACCCCGAGTTCGCAACCATCCTC
CGGGTGTTCGGCGCCATGGGATTCCGGTTGACGGCAGAACTGGCCGAAAATAAGCCGAGAAGGAAAGCAGTGGCCTGA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10243.59 Da Isoelectric Point: 4.5593
>AT169706 WP_083012385.1 NZ_CP060015:c4146979-4146701 [Mycobacterium malmoense]
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQELMREVRAAEAESGQTYTLDEV
TAEMRAAGRLPR
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQELMREVRAAEAESGQTYTLDEV
TAEMRAAGRLPR
Download Length: 279 bp
>AT169706 NZ_CP076676:c1701988-1701695 [Rhodopseudomonas palustris]
ATTGACGTTCGCGAAACACTGGACTTCACGAACTGGCTCGCCGCCTTGAGTGACCTGCGCGCCCGTCTGCAGATCGTTCG
CCGGATCGACCGGATTGCCGCGGGAAACTTCGGTGAAGCCAAATCGGTTGGTGGCGCGGTGAAGGAGCTTCGGATCGACT
ACGGACCGGGCTACCGAGTTTACTACACGCGGCGCGGCGACACCGTCGTCATCCTGCTCTGCGGCGGCGACAAGCGGACG
CAAAGCAAGGACATCCGGAAGGCTAAGGAAATTGCAGAGGCGTTGGAGGACTGA
ATTGACGTTCGCGAAACACTGGACTTCACGAACTGGCTCGCCGCCTTGAGTGACCTGCGCGCCCGTCTGCAGATCGTTCG
CCGGATCGACCGGATTGCCGCGGGAAACTTCGGTGAAGCCAAATCGGTTGGTGGCGCGGTGAAGGAGCTTCGGATCGACT
ACGGACCGGGCTACCGAGTTTACTACACGCGGCGCGGCGACACCGTCGTCATCCTGCTCTGCGGCGGCGACAAGCGGACG
CAAAGCAAGGACATCCGGAAGGCTAAGGAAATTGCAGAGGCGTTGGAGGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|