Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3104063..3104660 Replicon chromosome
Accession NZ_CP060015
Organism Mycobacterium malmoense strain DSM 44163

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag H5T25_RS14510 Protein ID WP_083012607.1
Coordinates 3104063..3104431 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag H5T25_RS14515 Protein ID WP_071509019.1
Coordinates 3104424..3104660 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5T25_RS24955 (H5T25_14370) 3099682..3100980 - 1299 WP_176220077.1 PE family protein -
H5T25_RS14495 (H5T25_14375) 3101479..3102393 + 915 WP_230981261.1 tyrosine-type recombinase/integrase -
H5T25_RS14500 (H5T25_14380) 3102461..3102579 + 119 Protein_2882 ATPase -
H5T25_RS14505 (H5T25_14385) 3103654..3103947 + 294 WP_139797206.1 hypothetical protein -
H5T25_RS14510 (H5T25_14390) 3104063..3104431 - 369 WP_083012607.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H5T25_RS14515 (H5T25_14395) 3104424..3104660 - 237 WP_071509019.1 antitoxin Antitoxin
H5T25_RS14520 (H5T25_14400) 3105144..3106340 - 1197 WP_139797207.1 hypothetical protein -
H5T25_RS14525 (H5T25_14405) 3106975..3108006 - 1032 WP_176220078.1 AAA family ATPase -
H5T25_RS14530 (H5T25_14410) 3108232..3109512 - 1281 WP_071509016.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3099682..3122675 22993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 12736.68 Da        Isoelectric Point: 6.0706

>T169704 WP_083012607.1 NZ_CP060015:c3104431-3104063 [Mycobacterium malmoense]
MPEPRRGELWLVALGAARAGGPGKHHPAVVVSVDEILTGLDDELVVVVPVSSSRSGSPLRPPVMPAEGVDTQSVAVCRDI
RAVARSRLVERLGTVAPDTMHGIEHALGLILGVDTGLSPPSW

Download         Length: 369 bp

>T169704 NZ_CP076668:c5346618-5346343 [Pseudomonas lijiangensis]
ATGGAGTTGAAGTGGACAAGCAAAGCGCTCTCCGACATTGCCAGATTGTACGAATTTCTTGCTGCTGTGAATCAGCCTGC
CGCTGCCCATACGGTTCAACAACTCACTGCTGCTCCGACCATTTTGCTGACTAACCCCCGCATTGGGGAATACCTTGAAG
AGTTTGAACCTCGTGATGTGCGTCGAATCCTGATCGGGCACTACGAGCTGCGCTATGAAATAAAGGGCCCCACTATTTAC
CTGTTGCGTCTGTGGCATACACGCGAAGATCGGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8404.25 Da        Isoelectric Point: 4.5742

>AT169704 WP_071509019.1 NZ_CP060015:c3104660-3104424 [Mycobacterium malmoense]
MSTSTTTIRVSVRTRDRLVAQARQRGISLAGLVTELASRAEQEAVFRAERDATLADAGIAGVREEDRDWDDTAGDGIA

Download         Length: 237 bp

>AT169704 NZ_CP076668:c5346890-5346618 [Pseudomonas lijiangensis]
ATGACAACTACCGCTAAAACTCGATCTGTCACAGCTCACGTGCCAGTCCACCTGGCTGAGAAAATCGACATGATGGCTGA
GCGTCTGGAGCGTTCAAGAAACTGGATCGTCAAACAGGCTCTTTGTGCCTGGATTGATCAGGAAGAAGAGCGCAGCCGCT
TGACTCGAGAGGCCTTGGCAGATGTGGACGCTGGCCGCGTTATTGAGCATCAGGCTGTTCAGGCATGGGCGGATAGCCTC
AGCACCGAGACTCCGTTACCGGTGCCGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References