Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2264081..2264610 Replicon chromosome
Accession NZ_CP060015
Organism Mycobacterium malmoense strain DSM 44163

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag H5T25_RS10720 Protein ID WP_071510051.1
Coordinates 2264081..2264338 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H5T25_RS10725 Protein ID WP_083011676.1
Coordinates 2264335..2264610 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5T25_RS10690 (H5T25_10605) 2259758..2260480 + 723 WP_083011669.1 hypothetical protein -
H5T25_RS10695 (H5T25_10610) 2260561..2260713 + 153 Protein_2124 type II toxin-antitoxin system VapB family antitoxin -
H5T25_RS10700 (H5T25_10615) 2260811..2261195 + 385 Protein_2125 VapC toxin family PIN domain ribonuclease -
H5T25_RS10705 (H5T25_10620) 2261309..2261557 - 249 WP_083011671.1 hypothetical protein -
H5T25_RS10710 (H5T25_10625) 2262092..2263258 + 1167 WP_139797141.1 hypothetical protein -
H5T25_RS10715 (H5T25_10630) 2263378..2264031 + 654 WP_083011727.1 DUF5642 family protein -
H5T25_RS10720 (H5T25_10635) 2264081..2264338 - 258 WP_071510051.1 Txe/YoeB family addiction module toxin Toxin
H5T25_RS10725 (H5T25_10640) 2264335..2264610 - 276 WP_083011676.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H5T25_RS10730 (H5T25_10645) 2264868..2265512 - 645 WP_139797142.1 hypothetical protein -
H5T25_RS10735 (H5T25_10650) 2265654..2266211 - 558 WP_071510053.1 hypothetical protein -
H5T25_RS10740 (H5T25_10655) 2267301..2267813 + 513 WP_071510054.1 MarR family transcriptional regulator -
H5T25_RS10745 (H5T25_10660) 2268014..2268673 + 660 WP_071510055.1 DUF5642 family protein -
H5T25_RS10750 (H5T25_10665) 2268687..2269178 - 492 WP_071510056.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2241222..2289692 48470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10129.45 Da        Isoelectric Point: 10.1305

>T169701 WP_071510051.1 NZ_CP060015:c2264338-2264081 [Mycobacterium malmoense]
VRSIHFDPNAWEDFLFWLGSDRKAARRVTRLIAEVQRDPFRGTGKPEPLKGELSGYWSRRIDDQHRLVYRADGDEVKILK
ARYHY

Download         Length: 258 bp

>T169701 NZ_CP076668:c829284-828709 [Pseudomonas lijiangensis]
ATGAGGCATTCACCGTTCACTGCTTTCTATGACGCGAATGTTCTCTATCCTGCACCTCTACGTGACTTCTTGATGCACTT
GGCACTGAGCGGCGTGTATCGCGCACGCTGTTCAGCTCAGATACATGAGGAGTGGAAACGTAATCTTCTCATCAATCGTC
CCGAACTCACTCGCGAGCAATTGGATCGAACTGCCGCCTTGATGGATAAAGCTGTACCTGATGCCTTAGTGATGGACTAC
GAACCTCTAATTGAAGGGCTTACACTGCCCGATACAGATGATCGTCACGTACTTGCTGCCGCAATCAAATGCAATGCGTC
TGTCATTGTTACGTTTAACCTTAAAGACTTTCCAAAGAGCGCTCTTGAAGCGTTTGATATCGAACCTCTGCACCCTGATG
ACTTCATTGCCGACCTTTGGGATCTGGATCAGGCTGCGGTTCTTGAAGCGGCGCAACGGCAGAGAGCATCGCTGAAAAAC
CCACCGCATAGTGCGCGACAATACCTGGACAAGTTGCTACAGCAGCAGCTTCCGGAAACCGTAAAACTGCTGTCTGGTTT
TGAGTTCCTGATTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10108.34 Da        Isoelectric Point: 5.0622

>AT169701 WP_083011676.1 NZ_CP060015:c2264610-2264335 [Mycobacterium malmoense]
MSISASEARQRLYPLLAQVNTDHQPVRITSKAGDAVLMSADDYDSWQETVYLLRSPKNAQRLMEAVARDKAGHFALTKSV
DELQEMAGGQE

Download         Length: 276 bp

>AT169701 NZ_CP076668:c829748-829281 [Pseudomonas lijiangensis]
ATGACCACCGTCGGCCTCACTCGCACCGTTCTCCCCGATGAGAAAGAAATCGCTGCGGCTGTGGCGTCAAGCCGCCAGTT
AGCCGCATTTCTTTCGACAAAATGTGAAACTCAGTGCATTGAGTTGATTGATGACACGCAGCAGCGTGAAGTCGTTGAAT
TACCTACTTTCGCCCTGCGCTTACTCGGAGAAATCCTGAGCGAGCTTGCGCTGGGCAATGCCGTCAAAGTCGTTCCTATT
CATGCAGAACTGACTACTCAGGAAGGCGCTGACATGCTCAACGTTTCTCGACCTCACCTGGTAAAGCTACTGGACCAAGG
CGCGTTGCCGCACACAAAAACCGGTCGACATCGCAGGATCAAATTCGCAGACCTGATGGCTTACAAAGAGCAGCGCGACC
AGGCAAGCCGGGATGCCATGGATGAACTCGCAGCACAAGCACAGGAGTTAGGGATGGGGTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References