Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2245500..2246128 Replicon chromosome
Accession NZ_CP060015
Organism Mycobacterium malmoense strain DSM 44163

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H5T25_RS10620 Protein ID WP_083011642.1
Coordinates 2245715..2246128 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H5T25_RS10615 Protein ID WP_071510089.1
Coordinates 2245500..2245724 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5T25_RS10585 (H5T25_10505) 2240738..2241109 - 372 WP_083010903.1 hypothetical protein -
H5T25_RS10590 (H5T25_10510) 2241222..2241872 - 651 WP_139797002.1 hypothetical protein -
H5T25_RS10595 (H5T25_10515) 2242278..2242838 - 561 WP_071513463.1 MarR family transcriptional regulator -
H5T25_RS10600 (H5T25_10520) 2243732..2244031 + 300 WP_220688608.1 PE family protein -
H5T25_RS10605 2244089..2244465 + 377 Protein_2106 PPE family protein -
H5T25_RS10610 2244931..2245266 + 336 WP_265415743.1 hypothetical protein -
H5T25_RS10615 (H5T25_10530) 2245500..2245724 + 225 WP_071510089.1 hypothetical protein Antitoxin
H5T25_RS10620 (H5T25_10535) 2245715..2246128 + 414 WP_083011642.1 PIN domain nuclease Toxin
H5T25_RS10625 (H5T25_10540) 2246990..2247565 + 576 Protein_2110 PPE family protein -
H5T25_RS10630 (H5T25_10545) 2247793..2248173 + 381 WP_265415740.1 PE/PPE C-terminal domain-containing protein -
H5T25_RS10635 (H5T25_10550) 2248255..2249055 + 801 WP_230981670.1 sulfotransferase -
H5T25_RS10640 (H5T25_10555) 2249544..2249876 + 333 WP_139797137.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2241222..2289692 48470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(24-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14950.17 Da        Isoelectric Point: 8.5681

>T169700 WP_083011642.1 NZ_CP060015:2245715-2246128 [Mycobacterium malmoense]
VAVTRWLIDKSAYARLQLGQASNVDQWNARIGRGLVHLSTITRLELGYSARNGHAGRRQFASPPLSLMPVEYLTPAIEDR
ALEVQMLLADRGQHRAPSIPDLLVAATAEKAGLRVLVADKDFDLIANITGQPIDALT

Download         Length: 414 bp

>T169700 NZ_CP076660:c2197392-2197126 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGATCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8176.19 Da        Isoelectric Point: 4.3867

>AT169700 WP_071510089.1 NZ_CP060015:2245500-2245724 [Mycobacterium malmoense]
MPDVLIRGLSEEAVENIDAAAAALGLSRNEYLRRTFERAAVQPVKKTVTAEDWQRSAETFADLADPDVMAAAWR

Download         Length: 225 bp

>AT169700 NZ_CP076660:c2197649-2197392 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References