Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN-PHD |
Location | 2066935..2067569 | Replicon | chromosome |
Accession | NZ_CP060015 | ||
Organism | Mycobacterium malmoense strain DSM 44163 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | H5T25_RS09805 | Protein ID | WP_083013017.1 |
Coordinates | 2066935..2067327 (-) | Length | 131 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | H5T25_RS09810 | Protein ID | WP_071508812.1 |
Coordinates | 2067324..2067569 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H5T25_RS09785 (H5T25_09710) | 2063091..2064281 | + | 1191 | WP_139797092.1 | hypothetical protein | - |
H5T25_RS09790 (H5T25_09715) | 2064956..2066221 | + | 1266 | WP_230981624.1 | group II intron reverse transcriptase/maturase | - |
H5T25_RS09795 (H5T25_09720) | 2066362..2066589 | + | 228 | WP_083013021.1 | ribbon-helix-helix domain-containing protein | - |
H5T25_RS09800 (H5T25_09725) | 2066586..2066888 | + | 303 | WP_083013019.1 | toxin | - |
H5T25_RS09805 (H5T25_09730) | 2066935..2067327 | - | 393 | WP_083013017.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
H5T25_RS09810 (H5T25_09735) | 2067324..2067569 | - | 246 | WP_071508812.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
H5T25_RS09815 (H5T25_09740) | 2067710..2070370 | - | 2661 | WP_083013015.1 | circularly permuted type 2 ATP-grasp protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14704.78 Da Isoelectric Point: 5.9799
>T169698 WP_083013017.1 NZ_CP060015:c2067327-2066935 [Mycobacterium malmoense]
VKRYLVDTHVWLWMQSDPDRLRDEAREIVQDARNSVLLSAASAWEIAIKYRLGKLPLPEAPASYLPDRMRRSGTSPLPVD
HAHALRTAELPDHHRDPFDRLLIAQAQLLDLTIMTADEQLSAYDVAVVAA
VKRYLVDTHVWLWMQSDPDRLRDEAREIVQDARNSVLLSAASAWEIAIKYRLGKLPLPEAPASYLPDRMRRSGTSPLPVD
HAHALRTAELPDHHRDPFDRLLIAQAQLLDLTIMTADEQLSAYDVAVVAA
Download Length: 393 bp
>T169698 NZ_CP076660:c1881894-1881790 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGATTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGATTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9013.31 Da Isoelectric Point: 6.2190
>AT169698 WP_071508812.1 NZ_CP060015:c2067569-2067324 [Mycobacterium malmoense]
MTKSAAIRVGVHEAKTRMSELLRLVDSGQEIEIARGGEPVAKLVPFRSPEIRRLGIDHGVYAVPDDFDAPLPDDVLHSFY
R
MTKSAAIRVGVHEAKTRMSELLRLVDSGQEIEIARGGEPVAKLVPFRSPEIRRLGIDHGVYAVPDDFDAPLPDDVLHSFY
R
Download Length: 246 bp
>AT169698 NZ_CP076660:1881697-1881735 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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