Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 2066935..2067569 Replicon chromosome
Accession NZ_CP060015
Organism Mycobacterium malmoense strain DSM 44163

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H5T25_RS09805 Protein ID WP_083013017.1
Coordinates 2066935..2067327 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H5T25_RS09810 Protein ID WP_071508812.1
Coordinates 2067324..2067569 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5T25_RS09785 (H5T25_09710) 2063091..2064281 + 1191 WP_139797092.1 hypothetical protein -
H5T25_RS09790 (H5T25_09715) 2064956..2066221 + 1266 WP_230981624.1 group II intron reverse transcriptase/maturase -
H5T25_RS09795 (H5T25_09720) 2066362..2066589 + 228 WP_083013021.1 ribbon-helix-helix domain-containing protein -
H5T25_RS09800 (H5T25_09725) 2066586..2066888 + 303 WP_083013019.1 toxin -
H5T25_RS09805 (H5T25_09730) 2066935..2067327 - 393 WP_083013017.1 type II toxin-antitoxin system VapC family toxin Toxin
H5T25_RS09810 (H5T25_09735) 2067324..2067569 - 246 WP_071508812.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
H5T25_RS09815 (H5T25_09740) 2067710..2070370 - 2661 WP_083013015.1 circularly permuted type 2 ATP-grasp protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-128)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-48)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14704.78 Da        Isoelectric Point: 5.9799

>T169698 WP_083013017.1 NZ_CP060015:c2067327-2066935 [Mycobacterium malmoense]
VKRYLVDTHVWLWMQSDPDRLRDEAREIVQDARNSVLLSAASAWEIAIKYRLGKLPLPEAPASYLPDRMRRSGTSPLPVD
HAHALRTAELPDHHRDPFDRLLIAQAQLLDLTIMTADEQLSAYDVAVVAA

Download         Length: 393 bp

>T169698 NZ_CP076660:c1881894-1881790 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGATTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9013.31 Da        Isoelectric Point: 6.2190

>AT169698 WP_071508812.1 NZ_CP060015:c2067569-2067324 [Mycobacterium malmoense]
MTKSAAIRVGVHEAKTRMSELLRLVDSGQEIEIARGGEPVAKLVPFRSPEIRRLGIDHGVYAVPDDFDAPLPDDVLHSFY
R

Download         Length: 246 bp

>AT169698 NZ_CP076660:1881697-1881735 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References