Detailed information of TA system TA169697

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 2066362..2066888
• Replicon: chromosome
• Accession: NZ_CP060015
• Organism: Mycobacterium malmoense strain DSM 44163

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: H5T25_RS09800
• Protein ID: WP_083013019.1
• Coordinates: 2066586..2066888 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: -
• Locus tag: H5T25_RS09795
• Protein ID: WP_083013021.1
• Coordinates: 2066362..2066589 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5T25_RS09780 (H5T25_09705)	2061776..2062831	+	1056	WP_083011396.1	putative zinc-binding metallopeptidase	-
H5T25_RS09785 (H5T25_09710)	2063091..2064281	+	1191	WP_139797092.1	hypothetical protein	-
H5T25_RS09790 (H5T25_09715)	2064956..2066221	+	1266	WP_230981624.1	group II intron reverse transcriptase/maturase	-
H5T25_RS09795 (H5T25_09720)	2066362..2066589	+	228	WP_083013021.1	ribbon-helix-helix domain-containing protein	Antitoxin
H5T25_RS09800 (H5T25_09725)	2066586..2066888	+	303	WP_083013019.1	toxin	Toxin
H5T25_RS09805 (H5T25_09730)	2066935..2067327	-	393	WP_083013017.1	type II toxin-antitoxin system VapC family toxin	-
H5T25_RS09810 (H5T25_09735)	2067324..2067569	-	246	WP_071508812.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
H5T25_RS09815 (H5T25_09740)	2067710..2070370	-	2661	WP_083013015.1	circularly permuted type 2 ATP-grasp protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10418.16 Da
• Isoelectric Point: 4.6251

>T169697 WP_083013019.1 NZ_CP060015:2066586-2066888 [Mycobacterium malmoense]
VISPGDIVPRRGSDHELYVVVLSNAIHLAAATGRVVACPFIPGRVPDDAMAMVVAVRQPEGTLLPELVQWLPLSALDEPI
GAVGAAALRETTTIVTALIS

Nucleotide

• Length: 303 bp

>T169697 NZ_CP076660:c1824345-1824136 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8319.39 Da
• Isoelectric Point: 10.1560

>AT169697 WP_083013021.1 NZ_CP060015:2066362-2066589 [Mycobacterium malmoense]
MAKRKISVTVDAHILAATDANARSAGLNRSEMIEQALRNEHLRIALHNYTNRTVPALDIDAYAQNVYRANRSSGL

Nucleotide

• Length: 228 bp

>AT169697 NZ_CP076660:c1824650-1824357 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA