Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 2066362..2066888 Replicon chromosome
Accession NZ_CP060015
Organism Mycobacterium malmoense strain DSM 44163

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag H5T25_RS09800 Protein ID WP_083013019.1
Coordinates 2066586..2066888 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID -
Locus tag H5T25_RS09795 Protein ID WP_083013021.1
Coordinates 2066362..2066589 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5T25_RS09780 (H5T25_09705) 2061776..2062831 + 1056 WP_083011396.1 putative zinc-binding metallopeptidase -
H5T25_RS09785 (H5T25_09710) 2063091..2064281 + 1191 WP_139797092.1 hypothetical protein -
H5T25_RS09790 (H5T25_09715) 2064956..2066221 + 1266 WP_230981624.1 group II intron reverse transcriptase/maturase -
H5T25_RS09795 (H5T25_09720) 2066362..2066589 + 228 WP_083013021.1 ribbon-helix-helix domain-containing protein Antitoxin
H5T25_RS09800 (H5T25_09725) 2066586..2066888 + 303 WP_083013019.1 toxin Toxin
H5T25_RS09805 (H5T25_09730) 2066935..2067327 - 393 WP_083013017.1 type II toxin-antitoxin system VapC family toxin -
H5T25_RS09810 (H5T25_09735) 2067324..2067569 - 246 WP_071508812.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
H5T25_RS09815 (H5T25_09740) 2067710..2070370 - 2661 WP_083013015.1 circularly permuted type 2 ATP-grasp protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10418.16 Da        Isoelectric Point: 4.6251

>T169697 WP_083013019.1 NZ_CP060015:2066586-2066888 [Mycobacterium malmoense]
VISPGDIVPRRGSDHELYVVVLSNAIHLAAATGRVVACPFIPGRVPDDAMAMVVAVRQPEGTLLPELVQWLPLSALDEPI
GAVGAAALRETTTIVTALIS

Download         Length: 303 bp

>T169697 NZ_CP076660:c1824345-1824136 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8319.39 Da        Isoelectric Point: 10.1560

>AT169697 WP_083013021.1 NZ_CP060015:2066362-2066589 [Mycobacterium malmoense]
MAKRKISVTVDAHILAATDANARSAGLNRSEMIEQALRNEHLRIALHNYTNRTVPALDIDAYAQNVYRANRSSGL

Download         Length: 228 bp

>AT169697 NZ_CP076660:c1824650-1824357 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References