Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-yefM/YoeB-YefM |
| Location | 605433..605932 | Replicon | chromosome |
| Accession | NZ_CP060015 | ||
| Organism | Mycobacterium malmoense strain DSM 44163 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | H5T25_RS02775 | Protein ID | WP_071508680.1 |
| Coordinates | 605433..605690 (-) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | - |
| Locus tag | H5T25_RS02780 | Protein ID | WP_071508681.1 |
| Coordinates | 605687..605932 (-) | Length | 82 a.a. |
Genomic Context
Location: 600954..601088 (135 bp)
Type: Others
Protein ID: WP_269142733.1
Type: Others
Protein ID: WP_269142733.1
Location: 601301..603160 (1860 bp)
Type: Others
Protein ID: WP_083012144.1
Type: Others
Protein ID: WP_083012144.1
Location: 603157..603816 (660 bp)
Type: Others
Protein ID: WP_083012146.1
Type: Others
Protein ID: WP_083012146.1
Location: 603853..605028 (1176 bp)
Type: Others
Protein ID: WP_071508678.1
Type: Others
Protein ID: WP_071508678.1
Location: 605028..605408 (381 bp)
Type: Others
Protein ID: WP_071508679.1
Type: Others
Protein ID: WP_071508679.1
Location: 606405..607598 (1194 bp)
Type: Others
Protein ID: WP_139797175.1
Type: Others
Protein ID: WP_139797175.1
Location: 608010..608828 (819 bp)
Type: Others
Protein ID: WP_083012151.1
Type: Others
Protein ID: WP_083012151.1
Location: 605433..605690 (258 bp)
Type: Toxin
Protein ID: WP_071508680.1
Type: Toxin
Protein ID: WP_071508680.1
Location: 605687..605932 (246 bp)
Type: Antitoxin
Protein ID: WP_071508681.1
Type: Antitoxin
Protein ID: WP_071508681.1
Location: 608847..609737 (891 bp)
Type: Others
Protein ID: WP_083012153.1
Type: Others
Protein ID: WP_083012153.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H5T25_RS24820 | 600954..601088 | + | 135 | WP_269142733.1 | hypothetical protein | - |
| H5T25_RS02755 (H5T25_02730) | 601301..603160 | + | 1860 | WP_083012144.1 | molecular chaperone DnaK | - |
| H5T25_RS02760 (H5T25_02735) | 603157..603816 | + | 660 | WP_083012146.1 | nucleotide exchange factor GrpE | - |
| H5T25_RS02765 (H5T25_02740) | 603853..605028 | + | 1176 | WP_071508678.1 | molecular chaperone DnaJ | - |
| H5T25_RS02770 (H5T25_02745) | 605028..605408 | + | 381 | WP_071508679.1 | helix-turn-helix domain-containing protein | - |
| H5T25_RS02775 (H5T25_02750) | 605433..605690 | - | 258 | WP_071508680.1 | Txe/YoeB family addiction module toxin | Toxin |
| H5T25_RS02780 (H5T25_02755) | 605687..605932 | - | 246 | WP_071508681.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| H5T25_RS02785 (H5T25_02760) | 606405..607598 | + | 1194 | WP_139797175.1 | hypothetical protein | - |
| H5T25_RS02790 (H5T25_02765) | 608010..608828 | + | 819 | WP_083012151.1 | class I SAM-dependent methyltransferase | - |
| H5T25_RS02795 (H5T25_02770) | 608847..609737 | - | 891 | WP_083012153.1 | aldose 1-epimerase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9963.26 Da Isoelectric Point: 8.4774
>T169695 WP_071508680.1 NZ_CP060015:c605690-605433 [Mycobacterium malmoense]
VRLVFTPLGWADYQYWSTTDRGTQKRINRLIDDTLRDPFAGIGKLEPLRHAFAGAWSRRISEEHRLVYLVDGDDVVIVQA
RYHYT
VRLVFTPLGWADYQYWSTTDRGTQKRINRLIDDTLRDPFAGIGKLEPLRHAFAGAWSRRISEEHRLVYLVDGDDVVIVQA
RYHYT
Download Length: 258 bp
>T169695 NZ_CP076660:c1708934-1708758 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9163.24 Da Isoelectric Point: 6.4705
>AT169695 WP_071508681.1 NZ_CP060015:c605932-605687 [Mycobacterium malmoense]
VAITASEARKNLFPLIEQVNNDRVPVEINSRRGDAVLISRADYEALEETAHLLRSPANARRLLESLTQAQRGEREEHTLS
R
VAITASEARKNLFPLIEQVNNDRVPVEINSRRGDAVLISRADYEALEETAHLLRSPANARRLLESLTQAQRGEREEHTLS
R
Download Length: 246 bp
>AT169695 NZ_CP076660:1708635-1708690 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG