Detailed information of TA system TA169695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 605433..605932
• Replicon: chromosome
• Accession: NZ_CP060015
• Organism: Mycobacterium malmoense strain DSM 44163

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H5T25_RS02775
• Protein ID: WP_071508680.1
• Coordinates: 605433..605690 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: H5T25_RS02780
• Protein ID: WP_071508681.1
• Coordinates: 605687..605932 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5T25_RS24820	600954..601088	+	135	WP_269142733.1	hypothetical protein	-
H5T25_RS02755 (H5T25_02730)	601301..603160	+	1860	WP_083012144.1	molecular chaperone DnaK	-
H5T25_RS02760 (H5T25_02735)	603157..603816	+	660	WP_083012146.1	nucleotide exchange factor GrpE	-
H5T25_RS02765 (H5T25_02740)	603853..605028	+	1176	WP_071508678.1	molecular chaperone DnaJ	-
H5T25_RS02770 (H5T25_02745)	605028..605408	+	381	WP_071508679.1	helix-turn-helix domain-containing protein	-
H5T25_RS02775 (H5T25_02750)	605433..605690	-	258	WP_071508680.1	Txe/YoeB family addiction module toxin	Toxin
H5T25_RS02780 (H5T25_02755)	605687..605932	-	246	WP_071508681.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H5T25_RS02785 (H5T25_02760)	606405..607598	+	1194	WP_139797175.1	hypothetical protein	-
H5T25_RS02790 (H5T25_02765)	608010..608828	+	819	WP_083012151.1	class I SAM-dependent methyltransferase	-
H5T25_RS02795 (H5T25_02770)	608847..609737	-	891	WP_083012153.1	aldose 1-epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9963.26 Da
• Isoelectric Point: 8.4774

>T169695 WP_071508680.1 NZ_CP060015:c605690-605433 [Mycobacterium malmoense]
VRLVFTPLGWADYQYWSTTDRGTQKRINRLIDDTLRDPFAGIGKLEPLRHAFAGAWSRRISEEHRLVYLVDGDDVVIVQA
RYHYT

Nucleotide

• Length: 258 bp

>T169695 NZ_CP076660:c1708934-1708758 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9163.24 Da
• Isoelectric Point: 6.4705

>AT169695 WP_071508681.1 NZ_CP060015:c605932-605687 [Mycobacterium malmoense]
VAITASEARKNLFPLIEQVNNDRVPVEINSRRGDAVLISRADYEALEETAHLLRSPANARRLLESLTQAQRGEREEHTLS
R

Nucleotide

• Length: 246 bp

>AT169695 NZ_CP076660:1708635-1708690 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG