Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 111011..111621 Replicon chromosome
Accession NZ_CP060015
Organism Mycobacterium malmoense strain DSM 44163

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H5T25_RS00560 Protein ID WP_083008796.1
Coordinates 111011..111403 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H5T25_RS00565 Protein ID WP_083008799.1
Coordinates 111400..111621 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5T25_RS00535 (H5T25_00535) 106638..107243 + 606 WP_139796726.1 class I SAM-dependent methyltransferase -
H5T25_RS00540 (H5T25_00540) 107356..107805 + 450 WP_083009126.1 nitroreductase family deazaflavin-dependent oxidoreductase -
H5T25_RS00545 (H5T25_00545) 107959..108633 - 675 WP_230981547.1 TetR/AcrR family transcriptional regulator -
H5T25_RS00550 (H5T25_00550) 108703..110400 + 1698 WP_176219862.1 FAD-dependent monooxygenase -
H5T25_RS00555 (H5T25_00555) 110418..110798 - 381 WP_230981548.1 hypothetical protein -
H5T25_RS00560 (H5T25_00560) 111011..111403 - 393 WP_083008796.1 PIN domain-containing protein Toxin
H5T25_RS00565 (H5T25_00565) 111400..111621 - 222 WP_083008799.1 CopG family transcriptional regulator Antitoxin
H5T25_RS00570 (H5T25_00570) 111704..113046 - 1343 Protein_110 aromatic ring-hydroxylating dioxygenase subunit alpha -
H5T25_RS00575 (H5T25_00575) 113058..114830 - 1773 WP_083008804.1 amidohydrolase family protein -
H5T25_RS00580 (H5T25_00580) 115010..116158 - 1149 WP_083008807.1 phosphotransferase -
H5T25_RS00585 (H5T25_00585) 116181..116558 - 378 WP_083009128.1 STAS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14877.74 Da        Isoelectric Point: 6.3775

>T169693 WP_083008796.1 NZ_CP060015:c111403-111011 [Mycobacterium malmoense]
MIFVDTSFWAALGNATDAHHTAAERLWAAKPPFVVTSNHVLGETWTLLNRRCGHRVAVTAAAIRYSSHVRLEHITAELEE
EAWEWLARHDEREYSFVDATSFALMRKKKLRDAYAFDEDFSAAGFVELRP

Download         Length: 393 bp

>T169693 NZ_CP076660:1553200-1553295 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGTGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8147.17 Da        Isoelectric Point: 4.7683

>AT169693 WP_083008799.1 NZ_CP060015:c111621-111400 [Mycobacterium malmoense]
MKRLQIYIEEDLDHALGIEARRQRKSKAALIRAYVADRLGAREPDPIDAFIGSFDGGVDLSTSVDDVVYGPRE

Download         Length: 222 bp

>AT169693 NZ_CP076660:c1553380-1553323 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References