Detailed information of TA system TA169692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 68375..68928
• Replicon: chromosome
• Accession: NZ_CP060015
• Organism: Mycobacterium malmoense strain DSM 44163

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H5T25_RS00330
• Protein ID: WP_083008730.1
• Coordinates: 68623..68928 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: H5T25_RS00325
• Protein ID: WP_083008727.1
• Coordinates: 68375..68626 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5T25_RS00300 (H5T25_00305)	63912..64103	-	192	WP_139796721.1	hypothetical protein	-
H5T25_RS00305 (H5T25_00310)	64196..65437	+	1242	WP_083008721.1	UPF0158 family protein	-
H5T25_RS00310 (H5T25_00315)	65609..66034	-	426	WP_071512775.1	type II toxin-antitoxin system VapC family toxin	-
H5T25_RS00315 (H5T25_00320)	66027..66278	-	252	WP_071512774.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
H5T25_RS00320 (H5T25_00325)	66994..68295	+	1302	WP_083008724.1	DUF2786 domain-containing protein	-
H5T25_RS00325 (H5T25_00330)	68375..68626	+	252	WP_083008727.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
H5T25_RS00330 (H5T25_00335)	68623..68928	+	306	WP_083008730.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H5T25_RS00335 (H5T25_00340)	69329..70333	+	1005	WP_071512769.1	glycoside hydrolase family 6 protein	-
H5T25_RS00340 (H5T25_00345)	70376..71407	-	1032	WP_083009110.1	fused (3R)-hydroxyacyl-ACP dehydratase subunits HadA/HadB	-
H5T25_RS00345 (H5T25_00350)	71629..71976	-	348	WP_083008733.1	hypothetical protein	-
H5T25_RS00350 (H5T25_00355)	72119..72718	-	600	WP_071512767.1	TetR/AcrR family transcriptional regulator	-
H5T25_RS00355 (H5T25_00360)	72827..73270	+	444	WP_083008736.1	DUF4345 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	67048..83797	16749

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11831.29 Da
• Isoelectric Point: 5.8965

>T169692 WP_083008730.1 NZ_CP060015:68623-68928 [Mycobacterium malmoense]
MSRHVLSPAAHADLEQIWDYTCERWDDDQAEEYVREIQRAIDRVVDNPMIGRACDEVRPGYRKHTVGSHTLYCRIARGDV
IDVVRILHQRMDVDRHLDSGM

Nucleotide

• Length: 306 bp

>T169692 NZ_CP076660:c548820-548632 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9524.44 Da
• Isoelectric Point: 8.7905

>AT169692 WP_083008727.1 NZ_CP060015:68375-68626 [Mycobacterium malmoense]
VGRNTSFSLDDHHRAFIEQEVASGRYRSASDVVRSALRLLEDRETRLSALRQALVTGEQSGESRPFDFDEFVARKRGENS
RRQ

Nucleotide

• Length: 252 bp

>AT169692 NZ_CP076660:c549109-548849 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA