Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 68375..68928 Replicon chromosome
Accession NZ_CP060015
Organism Mycobacterium malmoense strain DSM 44163

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag H5T25_RS00330 Protein ID WP_083008730.1
Coordinates 68623..68928 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag H5T25_RS00325 Protein ID WP_083008727.1
Coordinates 68375..68626 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5T25_RS00300 (H5T25_00305) 63912..64103 - 192 WP_139796721.1 hypothetical protein -
H5T25_RS00305 (H5T25_00310) 64196..65437 + 1242 WP_083008721.1 UPF0158 family protein -
H5T25_RS00310 (H5T25_00315) 65609..66034 - 426 WP_071512775.1 type II toxin-antitoxin system VapC family toxin -
H5T25_RS00315 (H5T25_00320) 66027..66278 - 252 WP_071512774.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
H5T25_RS00320 (H5T25_00325) 66994..68295 + 1302 WP_083008724.1 DUF2786 domain-containing protein -
H5T25_RS00325 (H5T25_00330) 68375..68626 + 252 WP_083008727.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
H5T25_RS00330 (H5T25_00335) 68623..68928 + 306 WP_083008730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H5T25_RS00335 (H5T25_00340) 69329..70333 + 1005 WP_071512769.1 glycoside hydrolase family 6 protein -
H5T25_RS00340 (H5T25_00345) 70376..71407 - 1032 WP_083009110.1 fused (3R)-hydroxyacyl-ACP dehydratase subunits HadA/HadB -
H5T25_RS00345 (H5T25_00350) 71629..71976 - 348 WP_083008733.1 hypothetical protein -
H5T25_RS00350 (H5T25_00355) 72119..72718 - 600 WP_071512767.1 TetR/AcrR family transcriptional regulator -
H5T25_RS00355 (H5T25_00360) 72827..73270 + 444 WP_083008736.1 DUF4345 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 67048..83797 16749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11831.29 Da        Isoelectric Point: 5.8965

>T169692 WP_083008730.1 NZ_CP060015:68623-68928 [Mycobacterium malmoense]
MSRHVLSPAAHADLEQIWDYTCERWDDDQAEEYVREIQRAIDRVVDNPMIGRACDEVRPGYRKHTVGSHTLYCRIARGDV
IDVVRILHQRMDVDRHLDSGM

Download         Length: 306 bp

>T169692 NZ_CP076660:c548820-548632 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9524.44 Da        Isoelectric Point: 8.7905

>AT169692 WP_083008727.1 NZ_CP060015:68375-68626 [Mycobacterium malmoense]
VGRNTSFSLDDHHRAFIEQEVASGRYRSASDVVRSALRLLEDRETRLSALRQALVTGEQSGESRPFDFDEFVARKRGENS
RRQ

Download         Length: 252 bp

>AT169692 NZ_CP076660:c549109-548849 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References