Detailed information of TA system TA169684

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 316801..317317
• Replicon: chromosome
• Accession: NZ_CP060009
• Organism: Pseudomonas sediminis strain B10D7D

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HNQ25_RS01500
• Protein ID: WP_143496206.1
• Coordinates: 316801..317088 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HNQ25_RS01505
• Protein ID: WP_143496205.1
• Coordinates: 317078..317317 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HNQ25_RS01480	312573..314375	+	1803	WP_179543461.1	SUMF1/EgtB/PvdO family nonheme iron enzyme	-
HNQ25_RS01485	314432..315319	+	888	WP_179543462.1	glycine zipper 2TM domain-containing protein	-
HNQ25_RS01490	315412..316317	+	906	WP_179543463.1	NAD synthetase	-
HNQ25_RS01495	316314..316763	+	450	WP_179543464.1	hypothetical protein	-
HNQ25_RS01500	316801..317088	-	288	WP_143496206.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HNQ25_RS01505	317078..317317	-	240	WP_143496205.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HNQ25_RS01510	317555..319975	-	2421	WP_106734034.1	DNA topoisomerase (ATP-hydrolyzing) subunit B	-
HNQ25_RS01515	319980..321083	-	1104	WP_179543465.1	DNA replication/repair protein RecF	-
HNQ25_RS01520	321083..322186	-	1104	WP_125834192.1	DNA polymerase III subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11268.11 Da
• Isoelectric Point: 10.0978

>T169684 WP_143496206.1 NZ_CP060009:c317088-316801 [Pseudomonas sediminis]
MIYSLEFDARALKEWHKLGDTVREQLKKKLAEVLVNPRVEANRLHSLPDCYKIKLRSSGYRLVYQVIDHEVVVFVVAVDR
RDREQAYRKAAERLK

Nucleotide

• Length: 288 bp

>T169684 NZ_CP076655:c34830-34414 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9066.51 Da
• Isoelectric Point: 4.8279

>AT169684 WP_143496205.1 NZ_CP060009:c317317-317078 [Pseudomonas sediminis]
MASINIRIDDELKVRAYRELEKLGVTPSELMRQALQYVAERGQLPFRPVLMTEEDEALIATVRERIAAPQRVKVSLDDL

Nucleotide

• Length: 240 bp

>AT169684 NZ_CP076655:c35057-34827 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA